39 documents found, page 1 of 4
Exogenous surfactant prevents hyperoxiainduced lung injury in adult mice.
Bezerra, Frank Silva; Ramos, Camila de Oliveira; Castro, Thalles de Freitas; Araújo, Natália Pereira da Silva; Souza, Ana Beatriz Farias deBackground: In addition to the risk of developing ventilator-induced lung injury, patients with ARDS are at risk of developing hyperoxic injury due the supra-physiological oxygen supplementation clinically required to reverse hypoxemia. Alterations of endogenous surfactant system participate in the pulmonary dysfunction observed in ARDS. Administration of exogenous surfactant could have protective effects durin...
Different source of commercial vegetable oils may regulate metabolic, inflammat...
Gomes, Sttefany Viana; Dias, Bruna Vidal; Pereira, Renata Rebeca; Lúcio, Karine de Pádua; Souza, Débora Maria Soares de; Silva, André Talvani Pedrosa daOur goal was to carry out a comparative study to evaluate the metabolic and inflammatory effects and the redox status of commercial vegetable oils supplementation [linseed (LO), coconut (VCO), and sunflower (SO)] in metabolically healthy rats. The results found in this study showed that the LO group decreased the HOMA-IR and hepatic cholesterol, and increased the serum levels of IL-6. Supplementation with VCO i...
Anti-Inflammatory and antioxidant properties of black mulberry (Morus nigra L.)...
Lúcio, Karine de Pádua; Rabelo, Ana Carolina Silveira; Araújo, Carolina Morais; Brandão, Geraldo Célio; Souza, Gustavo Henrique Bianco deSepsis is a complex disease and is the cause of many deaths worldwide. Sepsis pathogenesis involves a dysregulated inflammatory response with consequent production of inflammatory mediators and reactive species. The production and excessive release of these substances into the systemic circulation trigger various cellular and metabolic alterations that are observed during the disease evolution. Thus, more studi...
The β-blocker carvedilol and the benznidazole modulate the cardiac immune respo...
Horta, Aline Luciano; Figueiredo, Vivian Paulino; Leite, Ana Luísa Junqueira; Costa, Guilherme de Paula; Menezes, Ana Paula de JesusBACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57B...
Strength training session induces important changes on physiological, immunolog...
Fortunato, Ayla Karine; Pontes, Washington Martins; Souza, Débora Maria Soares de; Prazeres, Jéssica Santos Ferreira; Barbosa, Lucas Soares MarcucciStrength exercise is a strategy applied in sports and physical training processes. It may induce skeletal muscle hypertrophy. The hypertrophy is dependent on the eccentric muscle actions and on the inflammatory response. Here, we evaluate the physiological, immunological, and inflammatory responses induced by a session of strength training with a focus on predominance of the eccentric muscle actions. Twenty vol...
The administration of surfactant decreased oxidative stress in lungs of mice ex...
Machado, Dafne Fernandes; Campos, Keila Karine Duarte; Silva, Natália Pereira da; Ramos, Camila de Oliveira; Cangussú, Silvia DantasThe alveolar surfactant, which composition consists of a unique and complex mixture of lipids and proteins, has immunomodulatory action. This study aimed to evaluate the effects of exogenous surfactant on pulmonary inflammatory response in mice exposed to cigarette smoke (CS). Twenty-four mice C57BL/6 were divided into four groups: control group exposed to ambient air (CG); surfactant treated group (SG); CS exp...
High-Fat diet increases HMGB1 expression and promotes lung inflammation in mice...
Souza, Ana Beatriz Farias de; Chírico, Máira Tereza Talma; Cartelle, Christiane Teixeira; Costa, Guilherme de Paula; Silva, André Talvani Pedrosa daThis study aims to evaluate the effects of a high-fat diet and mechanical ventilation on the pulmonary and systemic inflammatory response in C57BL/6 mice. Male C57BL/6 mice were divided into two groups: one received a standard diet, and the other received a high-fat diet. After 10 weeks, the groups were further divided into two groups each: control group (CG), mechanical ventilation group (MVG), diet group (DG)...
Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypan...
Silva, M. C.; Azevedo, Maíra Araújo; Figueiredo, Vivian Paulino; Moura Junior, Manoel Ramos de; Coelho Júnior, Diógenes; Martinelli, Patrícia MassaraTrypanosoma cruzi triggers a progressive inflammatory response affecting cardiovascular functions in humans and experimental models. Angiotensin II, a key effector of the renin-angiotensin system, plays roles in mediating hypertension, heart failure, and inflammatory responses. T. cruzi and AngII can induce inflammatory responses by releasing inflammatory mediators. The aim of this study was to evaluate systemi...
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with ov...
Ribeiro, Silvana Mara Luz Turbino; Lopes, Laís Roquete; Costa, Guilherme de Paula; Figueiredo, Vivian Paulino; Bajracharya, Deena ShresthaThe current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears to contribute to the development of some obesity-related comorbidities. Interventions that directly or indirectly target individuals at high risk of developing obesity have been largely proposed because o...
Potential role of Carvedilol in the cardiac immune response induced by experime...
Horta, Aline Luciano; Leite, Ana Luísa Junqueira; Costa, Guilherme de Paula; Figueiredo, Vivian Paulino; Silva, André Talvani Pedrosa daTrypanosoma cruzi causes a cardiac infection characterized by an inflammatory imbalance that could become the inciting factor of the illness. To this end, we evaluated the role of carvedilol, a beta-blocker with potential immunomodulatory properties, on the immune response in C57BL/6 mice infected with VL-10 strain of T. cruzi in the acute phase. Animals ( = 40) were grouped: (i) not infected, (ii) infected, (i...