3 documents found, page 1 of 1
Cancer cells’ metabolism dynamics in renal cell carcinoma patients’ outcome: in...
Morais, Mariana; Dias, Francisca; Nogueira, Inês; Leão, Anabela; Gonçalves, Nuno; Araújo, Luís; Granja, Sara Costa; Baltazar, Fátima; Teixeira, Ana L.The cancer cells’ metabolism is altered due to deregulation of key proteins, including glucose transporter 1 (GLUT-1), whose mRNA levels are influenced by microRNAs (miRNAs). Renal cell carcinoma (RCC) is the most common and lethal neoplasia in the adult kidney, mostly due to the lack of accurate diagnosis and follow-up biomarkers. Being a metabolic associated cancer, this study aimed to understand the hsa-miR-...
Automated Identification and Classification of Stereochemistry: Chirality and D...
Leal, João P.; Falcao, Andre O.; Teixeira, Ana L.Stereoisomers have the same molecular formula and the same atom connectivity and their existence can be related to the presence of different three-dimensional (3D) arrangements. Stereoisomerism is of great importance in many different fields since the molecular properties and biological effects of the stereoisomers are often significantly different. Most drugs for example, are often composed of a single stereoi...
ThermInfo: Collecting, Retrieving, and Estimating Reliable Thermochemical Data
Teixeira, Ana L.; Santos, Rui C.; Leal, João P.; Martinho Simões, José A.; Falcao, Andre OStandard enthalpies of formation are used for assessing the efficiency and safety of chemical processes in the chemical industry. However, the number of compounds for which the enthalpies of formation are available is many orders of magnitude smaller than the number of known compounds. Thermochemical data prediction methods are therefore clearly needed. Several commercial and free chemical databases are current...