182 documents found, page 1 of 19
Advances on the Synthesis, Reactivity, and Biological Properties of 4<i>H</i>‐T...
Santos, Clementina M.M.; Silva, ArturThe aim of the present review is to provide a systematic survey on the recent advancements in the chemical synthesis of thiochromones, thiochromanones, the less explored thiochromene-4-thiones and some analogs. These compounds are used as versatile building blocks in the synthesis of other complex and polycyclic heterocyclic analogs. Highlights on biological and photophysical properties of these thio derivative...
Six-membered ring systems: With O and/or S atoms
Santos, Clementina M.M.; Silva, ArturThis chapter covers the most recent advances on the synthesis of O- and S-6-membered heterocycles reported during 2022. This personal overview is focused on the new achievements made in the synthesis of several natural compounds, specific reactions and reagents for the preparation of natural and synthetic pyrans, chromenes and chromans, isochromenes and isochromans, pyranones, coumarins and isocoumarins, chromo...
2-Styrylchromones as inhibitors of α-amylase and α-glucosidase enzymes for the ...
Santos, Clementina M.M.; Proença, Carina; Freitas, Marisa; Araújo, Alberto N.; Silva, Artur; Fernandes, Eduardaalpha-amylase and alpha-glucosidase are key enzymes implicated in carbohydrate digestion and their inhibition has been suggested as a powerful approach for regulating blood glucose levels. The present work describes for the first time their inhibition by a group of twelve hydroxylated 2-styrylchromones (2-SC). Our findings revealed that 2-SC display strong systematic inhibition of alpha-glucosidase rather than ...
Effects of Summer Water Deficit Stress on Olive Fruits and Oil Quality
Araújo, Márcia; Rodrigues, Nuno; Santos, Conceição; Pinto, Diana; Pereira, J.A.; Silva, Artur; Dias, Maria CelesteThe Mediterranean basin is the leading worldwide region for olive production. Extreme weather is increasingly frequent in this region, and how these climate extremes will affect olive products and quality remains unknown. We aim to study the effects of the water deficit stress, which occurred in the summer of 2017, on olive fruit and oil quality from a 30-year-old orchard. Fruits from olive trees standing on (i...
Transition Metal‐Catalyzed Transformations of Chalcones
Santos, Clementina M.M.; Silva, ArturChalcones are a class of naturally occurring flavonoid compounds associated to a variety of biological and pharmacological properties. Several reviews have been published describing the synthesis and biological properties of a vast array of analogues. However, overviews on the reactivity of chalcones has only been explored in a few accounts. To fill this gap, a systematic survey on the most recent developments ...
Vasculite Leucocitoclástica: Um Fenómeno Paraneoplásico Raro na Neoplasia do Ov...
Morais, Joana; Noversa Sousa, Rita; Rodrigues dos Santos, Raquel; Silva, Artur; Rosário, CristinaA vasculite leucocitoclástica (VLC) é um processo inflamatório que afeta vasos sanguíneos de pequeno calibre, na maioria das vezes secundária a determinada patologia, mas descrições da sua associação com neoplasias sólidas são raras. Apresentamos o caso de uma doente de 75 anos com um exantema macular eritematoso e púrpura palpável nos membros, cuja biópsia cutânea revelou VLC, como única manifestação de neopla...
Six-membered ring systems: with O and/or S atoms
Santos, Clementina M.M.; Silva, ArturThe most important achievements on the synthesis of O- and S-6-membered heterocycles published in 2021 are reviewed. This personal overview is focused on the developments made on the synthesis of a large variety of natural compounds, specific reactions, and reagents for the preparation of natural and synthetic pyrans, chromenes and chromans, isochromenes and isochromans, pyranones, coumarins and isocoumarins, c...
Draft genome sequence of the Brazilian toxic bloom-forming cyanobacterium Micro...
Fiore, Marli F.; Alvarenga, Danillo O.; Varani, Alessandro M. [UNESP]; Hoff-Risseti, Caroline; Crespim, Elaine; Ramos, Rommel T.J.; Silva, ArturMade available in DSpace on 2022-04-29T07:55:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Microcystis aeruginosa strain SPC777 is an important toxin-producing cyanobacterium, isolated from a water bloom of the Billings reservoir (São Paulo State, Brazil). Here, we report the draft genome sequence and initial findings from a preli...
Analysis of the antidiabetic potential of natural xanthones through the inhibit...
Santos, Clementina M.M.; Proença, Carina; Freitas, Marisa; Araújo, Alberto N.; Silva, Artur; Fernandes, EduardaDiabetes mellitus (DM) is a complex endocrine disorder associated with a state of hyperglycemia caused by the deficiency in the secretion of insulin and/or in the action of this pancreatic hormone. Thus, the control of postprandial blood glucose level via the inhibition of carbohydrate-hydrolyzing enzymes, such as α‐amylase and α‐glucosidase, is a consistent strategy for the management of type 2 DM and its rela...
Analysis of the antidiabetic potential of natural xanthones through the inhibit...
Santos, Clementina M.M.; Proença, Carina; Freitas, Marisa; Araújo, Alberto N.; Silva, Artur; Fernandes, EduardaDiabetes mellitus (DM) is a complex endocrine disorder associated with a state of hyperglycemia caused by the deficiency in the secretion of insulin and/or in the action of this pancreatic hormone. Thus, the control of postprandial blood glucose level via the inhibition of carbohydrate-hydrolyzing enzymes, such as α‐amylase and α‐glucosidase, is a consistent strategy for the management of type 2 DM and its rela...