164 documents found, page 1 of 17
Monoterpene hydroxy lactones isolated from Thalassiosira sp. microalga and thei...
Morais, Alcina M. M. B.; Kumla, Decha; Martins, Valter F. R.; Alves, Ana; Gales, Luis; Silva, Artur M. S.; Costa, Paulo M.; Mistry, SharadTwo monoterpenoid lactones, loliolide (1) and epi-loliolide (2), were isolated from the crude dichloromethane extract of a microalga, Thalassiosira sp.). The structures of loliolide (1) and epi-loliolide (2) were elucidated by 1D and 2D NMR analysis, as well as a comparison of their 1H or/and 13C NMR data with those reported in the literature. In the case of loliolide (1), the absolute configurations of its ste...
Exploring the fate of phlorotannins from Laminaria digitata across the gastroin...
Catarino, Marcelo D.; García, Carlos J.; García-Villalba, Rocío; Silva, Artur M. S.; Campos, Débora A.; Pintado, Maria Manuela; Neves, BrunoPhlorotannins are phenolic compounds exclusive from brown macroalgae endowed with promising bioactive properties. However, considering that diet is their main route of entrance to our system, gastrointestinal digestion might affect such bioactive properties. Here, phlorotannin extracts obtained from Laminaria digitata were submitted to simulated gastrointestinal digestion to evaluate its impact on their antioxi...
Influenza A virus propagation requires the activation of the unfolded protein r...
Marques, Mariana; Ramos, Bruno; Albuquerque, Hélio; Pereira, Marisa; Ribeiro, Diana Roberta; Nunes, Alexandre; Sarabando, Jéssica; Brás, DanielaInfluenza A virus (IAV) employs multiple strategies to manipulate cellular mechanisms and support proper virion formation and propagation. In this study, we performed a detailed analysis of the interplay between IAV and the host cells’ proteostasis throughout the entire infectious cycle. We reveal that IAV infection activates the inositol requiring enzyme 1 (IRE1) branch of the unfolded protein response, and th...
Recent advances in fluorescent theranostics for Alzheimer's disease: a comprehe...
Francisco, Telmo N.; Malafaia, Daniela; Melo, Lúcia; Silva, Artur M. S.; Albuquerque, Hélio M. T.Alzheimer's disease (AD) is the most common form of neurodegenerative dementia that is rapidly becoming a major health problem, especially in developed countries because of their increasing life expectancy. Two main problems are often associated with the disease: (i) the absence of a widely accessible "gold-standard" for early diagnosis and (ii) lack of effective therapies with disease-modifying effects. The re...
Metabolomics as a Tool to Understand Nano-Plant Interactions: The Case Study of...
Silva, Sónia; Dias, Maria Celeste; Pinto, Diana C. G. A.; Silva, Artur M. S.Metabolomics is a powerful tool in diverse research areas, enabling an understanding of the response of organisms, such as plants, to external factors, their resistance and tolerance mechanisms against stressors, the biochemical changes and signals during plant development, and the role of specialized metabolites. Despite its advantages, metabolomics is still underused in areas such as nano-plant interactions. ...
Exploiting the Integrated Valorization of Eucalyptus globulus Leaves: Chemical ...
Oliveira, Cátia S. D.; Moreira, Patrícia; Cruz, Maria T.; Pereira, Cláudia M. F.; Silva, Artur M. S.; Santos, Sónia A. O.; Silvestre, Armando J. D.E. globulus leaves have been mainly exploited for essential oil recovery or for energy generation in industrial pulp mills, neglecting the abundance of valuable families of extractives, namely, triterpenic acids, that might open new ways for the integrated valorization of this biomass. Therefore, this study highlights the lipophilic characterization of E. globulus leaves before and after hydrodistillation, aimi...
An integrated green process for the extraction of triterpenic acids fromEucalyp...
Oliveira, Cátia S. D.; Moreira, Patrícia; Cruz, Maria T.; Pereira, Cláudia M. F.; Gaspar, Alexandre; Neto, Carlos Pascoal; Pinto, Paula C. R. O.In this study the viability of the integrated exploitation of E. globulus leaf essential oil and triterpenic acids was evaluated through the development of a novel extraction process that can be implemented sequentially in a biorefinery context. Thus, essential oil (EO) collected by hydrodistillation was used for the first time as a bio-based solvent to recover triterpenic acids (TTAs) from the residue resultin...
Pyrazoles as potential modulators of inflammation through the inhibition of COX...
Silva, Jorge; Rocha, Sónia; Silva, Vera L. M.; Silva, Artur M. S.; Moreira, Fernando; Fernandes, Eduarda; Freitas, MarisaThe inflammatory process is a complex and tightly regulated cascade of events that involves the production of prostaglandins (PG) by the inducible isoform cyclooxygenase 2 (COX-2) and the production of reactive pro-oxidant species. When the production of these mediators becomes excessive, it can lead to chronic inflammation and associated diseases such as diabetes, rheumatoid arthritis, and cancer. Unfortunatel...
Drug discovery based on oxygen and nitrogen (non-)heterocyclic compounds develo...
Sousa, Joana L. C.; Albuquerque, Hélio M. T.; Silva, Artur M. S.Artur Silva's research group has a long history in the field of medicinal chemistry. The development of new synthetic methods for oxygen (mostly polyphenols, e.g., 2- and 3-styrylchromones, xanthones, flavones) and nitrogen (e.g., pyrazoles, triazoles, acridones, 4-quinolones) heterocyclic compounds in order to be assessed as antioxidant, anti-inflammatory, antidiabetic, and anticancer agents has been the main ...
2,2’-[(1E,1’E)-{[Hexa-2,4-diyne-1,6-diylbis(oxy)]bis(2,1-phenylene)}bis(ethene-...
Malafaia, Daniela; Sousa, Joana L. C.; Silva, Artur M. S.; Albuquerque, Hélio M. T.2-Styrylchromones (2-SCs) are interesting compounds for their biological properties as well as versatility as starting materials for further transformations. Herein, we disclose a new 2-SC derivative—2,2’-[(1E,1’E)-{[hexa-2,4-diyne-1,6-diylbis(oxy)]bis(2,1-phenylene)}bis(ethene-2,1- diyl)]bis(4H-chromen-4-one)—which is a dimeric compound formed by two units of 2-SC linked through a 1,3-diyne moiety. It was obta...