9 documents found, page 1 of 1
Mayaro virus induction of oxidative stress is associated with liver pathology i...
Caetano, Camila Carla da Silva; Camini, Fernanda Caetano; Almeida, Letícia Trindade; Ferraz, Ariane Coelho; Silva, Tales Fernando daMayaro virus (MAYV) causes Mayaro fever in humans, a self-limiting acute disease, with persistent arthralgia and arthritis. Although MAYV has a remerging potential, its pathogenic mechanisms remain unclear. Here, we characterized a model of MAYV infection in 3–4-week BALB/c mice. We investigated whether the liver acts as a site of viral replication and if the infection could cause histopathological alterations ...
Vertical Transmission of Zika Virus (Flaviviridae, Flavivirus) in Amazonian Aed...
Chaves, Bárbara Aparecida; Vieira Junior, Ademir Bentes; Silveira, Karine Renata Dias; Paz, Andréia da Costa; Vaz, Evelyn Beatriz da CostaZika virus (ZIKV) has emerged as a globally important arbovirus and has been reported from all states of Brazil. The virus is primarily transmitted to humans through the bite of an infective Aedes aegypti (Linnaeus, 1762) or Aedes albopictus (Skuse, 1895). However, it is important to know if ZIKV transmission also occurs from Ae. aegypti through infected eggs to her offspring. Therefore, a ZIKV and dengue virus...
Zika virus transmission to mouse ear by mosquito bite : a laboratory model that...
Secundino, Nagila Francinete Costa; Chaves, Bárbara Aparecida; Orfanó, Alessandra da Silva; Silveira, Karine Renata Dias; Rodrigues, Nilton BarnabéBackground: Zika disease has transformed into a serious global health problem due to the rapid spread of the arbovirus and alarming severity including congenital complications, microcephaly and Guillain-Barré syndrome. Zika virus (ZIKV) is primarily transmitted to humans through the bite of an infective mosquito, with Aedes aegypti being the main vector. Methods: We successfully developed a ZIKV experimental tr...
Coinfection with Zika Virus (ZIKV) and dengue virus results in preferential ZIK...
Chaves, Bárbara Aparecida; Orfanó, Alessandra da Silva; Nogueira, Paula Monalisa; Rodrigues, Nilton Barnabé; Campolina, Thaís BonifácioBackground. Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. Methods. A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating stra...
Aqueous extract of Baccharis trimera improves redox status and decreases the se...
Rabelo, Ana Carolina Silveira; Araújo, Glaucy Rodrigues de; Lúcio, Karine de Pádua; Araújo, Carolina Morais; Miranda, Pedro Henrique de AmorimThe metabolism of ethanol occurs mainly in the liver, promoting increase of reactive oxygen species and nitrogen, leading to redox imbalance. Therefore, antioxidants can be seen as an alternative to reestablish the oxidizing/reducing equilibrium. The aim of this study was to evaluate the antioxidant and hepatoprotective effect of aqueous extract of Baccharis trimera (Less.) DC., Asteraceae, in a model of hepato...
Distinct variation in vector competence among nine field populations of Aedes a...
Gonçalves, Caroline Macedo; Melo, Fabrício Freire de; Bezerra, Juliana Maria Trindade; Chaves, Bárbara Aparecida; Silva, Breno de MelloBrazil, dengue epidemics erupt sporadically throughout the country and it is unclear if outbreaks may initiate a sustainable transmission cycle. There are few studies evaluating the ability of Brazilian Aedes aegypti populations to transmit dengue virus (DENV). The aim of this study was to compare DENV susceptibility of field-captured Ae. aegypti populations from nine distinct geographic areas of the city of Be...
A tetravalent dengue nanoparticle stimulates antibody production in mice.
Silva, Elisângela; Orsi, Mariana; Andrade, Ângela Leão; Domingues, Rosana Zacarias; Silva, Breno de Mello; Araújo, Helena deDengue is a major public health problem worldwide, especially in the tropical and subtropical regions of the world. Infection with a single Dengue virus (DENV) serotype causes a mild, self-limiting febrile illness called dengue fever. However, a subset of patients experiencing secondary infection with a different serotype progresses to the severe form of the disease, dengue hemorrhagic fever/dengue shock syndro...
Oxidative stress in Mayaro virus infection.
Camini, Fernanda Caetano; Caetano, Camila Carla da Silva; Almeida, Letícia Trindade; Guerra, Joyce Ferreira da Costa; Silva, Breno de MelloMayaro virus (MAYV) is a neglected tropical arbovirus that causes a febrile syndrome that is sometimes accompanied by incapacitating arthritis/arthralgia. The pathogenesis of MAYV has not been completely defined and oxidative stress mediated by an increase in reactive oxygen species (ROS) and/or depletion of antioxidant defences has been found to contribute to several aspects of viral disease. To investigate wh...
Aedes (Stegomyia) albopictus’ dynamics influenced by spatiotemporal characteris...
Bezerra, Juliana Maria Trindade; Araújo, Raphaela Guedes Pereira; Melo, Fabrício Freire de; Gonçalves, Caroline Macedo; Chaves, Bárbara AparecidaBrazil reported the majority of the dengue cases in Americas during the last two decades, where theoccurrence of human dengue cases is exclusively attributed to the Aedes (Stegomyia) aegypti (Linnaeus).Nowadays, other recognized Dengue virus (DENV) vector in Asian countries, Aedes (Stegomyia) albopictus(Skuse), has been detected in more than half of the 5565 Brazilian municipalities. Therefore, the aim of thepr...