2 documents found, page 1 of 1
Conformational variability in sulfonamide chalcone hybrids : crystal structure ...
Castro, Mirian R. C. de; Aragão, Ângelo Q.; Silva, Cameron C. da; Perez, Caridad N.; Queiroz, Darlene P. K.; Queiroz Júnior, Luiz Henrique K.Four sulfonamide-chalcone derivatives were prepared and their crystal structure were elucidated by single-crystal X-ray diffraction technique. They were synthesized by Claisen-Schmidt condensation reaction between N -(4-acetylphenyl)benzenesulfonamide or N -(4-acetylphenyl)- 2,5-dichlorobenzenesulfonamide with benzaldehyde or p -nitrobenzaldehyde. Values of Z’ > 1 are found in three compounds as a consequence o...
Structure and cytotoxic activity of terpenoid-like chalcones
Lima, Rosa S.; Perez, Caridad N.; Silva, Cameron C. da; Santana, Mabio J.; Queiroz Júnior, Luiz H. K.; Barreto, StefânioCompounds with either ionone or chalcone skeletons present many biological properties including anticancer activity. Here we have prepared eight terpenoid-like chalcones in order to assess whether hybrid compounds with both structural frameworks could exhibit enhanced pharmacological profile. The terpenoid-like chalcones were synthesized by means of Claisen–Schmidt condensation reaction, using either α- or β-io...