162 documents found, page 1 of 17

Screening and in silico characterization of prophages in Helicobacter pylori cl...

The increase of antibiotic resistance calls for alternatives to control Helicobacter pylori, a Gram-negative bacterium associated with various gastric diseases. Bacteriophages (phages) can be highly effective in the treatment of pathogenic bacteria. Here, we developed a method to identify prophages in H. pylori genomes aiming at their future use in therapy. A polymerase chain reaction (PCR)-based technique test...

MultiWOZ-PT: A Task-oriented Dialogue Dataset in Portuguese

Despite the language widespread usage, publicly available and annotated Portuguese dialogue corpora are scarce. This poses a significant challenge in the development of effective dialogue systems that communicate in Portuguese. Having this in mind, we present MultiWOZ-PT, a new task-oriented dialogue dataset that results from the manual translation of dialogues in the MultiWOZ dataset to the European variety of...

Marie Curie – Uma mulher da Ciência

Marie Curie dedicou a sua vida à ciência numa época em que o mundo da ciência era essencialmente constituído por homens! Nasceu na Polónia em 1867, altura em que, por ser mulher, não lhe era permitido frequentar a universidade. Decidiu então ir estudar para França. Foi a primeira mulher a ganhar um prémio Nobel e a única pessoa até hoje a ganhar prémios Nobel em duas áreas distintas: na física e na química.

CC@UC: a construção colaborativa de um hub de ciência cidadã na Universidade de...

IMPORTING CORK FOR INSULATION INTO MONTANA MANUFACTURING: PORTUGAL INTERNATIONA...

This work aims to contribute to internationalization of "Amorim Cork Composites" and improve the quality of life in Montana through better thermal and sound insulation. The project involves collaboration between the Polytechnic Institute of Gaia and the University of Montana, focusing on research and practical implementation. It consists of three parts: the project's scope, including literature review and metho...

Voluntary exercise attenuates inflammaging in mice

Aging, one of the biggest health challenges of our time, is accompanied by various events, including an increase in inflammation levels (“inflammaging”), intestinal permeability, and dysbiosis of the intestinal microbiota. Gut bacterial dysbiosis contributes to aging by increasing gut permeability and giving rise to systemic inflammation, thus feeding this positive feedback loop. Given the central role of infla...

The impact of immunomodulation on host response and microbiota evolution

The interplay between gut microbiota and the host is important for immunity development, colonization resistance and host metabolism. Antibiotic use disrupts host-microbiota interactions, potentially decreasing the colonization resistance conferred by the gut microbiota. Lipopolysaccharide (LPS), an endotoxin present in Gram-negative bacteria, induces potent acute systemic inflammation. Nevertheless, it has als...

Voluntary exercise attenuates inflammaging in mice

Aging, one of the biggest health challenges of our time, is accompanied by numerous events, including an increase in inflammation levels (a process known as “inflammaging”), intestinal permeability, and dysbiotic alterations in the intestinal microbiota. Gut bacterial dysbiosis contributes to aging by increasing gut permeability and giving rise to systemic inflammation, thus feeding this positive feedback loop....

Epigenomics as a novel approach to explore the toxic effects of nanomaterials

In recent years, there has been a huge development of innovative engineered nanomaterials with potential use in industrial and biomedical applications. This increased widespread use raised concerns that nanomaterials may elicit human adverse health effects through occupational, environmental or consumer exposure. Many toxicity studies, mainly in vitro, have showed that some nanomaterials, such as carbon nanotub...

Effects of TiO2 Nanoparticles on the Genome-Wide Methylation of Human Epithelia...

Introduction: Titanium dioxide nanoparticles (TiO2NP) have multiple applications in industry (e.g., engineering, cosmetics, food additives), and biomedicine (e.g., targeted drug delivery and biosensing). Food-grade TiO2 (E171) is applied as a food additive to whiten and improve the opacity of food products, while also having the ability to enhance its flavour. In 2021, EU member states banned E171 from all food...