26 documents found, page 1 of 3
Evaluation of the occurrence of phthalates in plastic materials used in food pa...
Perestrelo, Rosa; Silva, Catarina L.; Algarra, Manuel; Câmara, José S.Phthalates are multifunctional synthetic chemicals found in a wide array of consumer and industrial products, mainly used to improve the mechanical properties of plastics, giving them flexibility and softness. In the European Union, phthalates are prohibited at levels greater than 0.1% by weight in most food packaging. In the current study, headspace solid-phase microextraction (HS SPME) combined with gas chrom...
Lipid biosignature of breast cancer tissues by matrix-assisted laser desorption...
Silva, Catarina L.; Perestrelo, Rosa; Sousa-Ferreira, Ivo; Capelinha, Filipa; Câmara, José S.; Petković, MarijanaPurpose One of the hallmarks of cancer cells is the demand of supply for the synthesis of new membranes involved in cell proliferation and lipids have an important role in cellular structure, signaling pathways and progression of cancer. In this sense, lipid studies have become an essential tool allowing the establishment of signatures associated with breast cancer (BC). In this regard, some metabolic processes...
Application of quality-by-design approach in the analytical method development ...
Silva, Pedro; Silva, Catarina L.; Perestrelo, Rosa; Nunes, Fernando M.; Câmara, José S.Produced in Madeira Island from regional sugarcane cultivars through a traditional manufacturing and storage process, sugarcane honey (SCH) is a black syrup recognized by its excellent quality. Its economic value has led to the emergence of adulterated SCH, whereby the identification of molecular markers became an essential task in order to overcome the fraudulent activities, protect its authenticity, and guara...
Monitoring phthalates in table and fortified wines by headspace solid-phase mic...
Perestrelo, Rosa; Silva, Catarina L.; Algarra, Manuel; Câmara, José S.Phthalates are a class of endocrine disruptors extensively used in plastic production as plasticizers, and as a result, they can be found in foods as a result of their migration ability. The occurrence of phthalates was monitored in 20 Portuguese wines using a simple, reliable, and environmentally friendly analytical method, headspace solid-phase microextraction combined with gas chromatography−mass spectrometr...
Implementing a central composite design for the optimization of solid phase mic...
Silva, Catarina L.; Perestrelo, Rosa Maria de Sá; Silva, Pedro; Tomás, Helena; Câmara, JoséIntroduction Breast cancer (BC) is positioned as the second among all cancers remaining at the top of women´s diseases worldwide followed by colorectum, lung, cervix, and thyroid cancers. The main drawback of most the screening/diagnostic methods is their low sensitivity/specificity and in some cases the invasive procedure required to obtain the samples. Objectives On the present investigation, we report a stat...
Untargeted urinary 1H NMR-based metabolomic pattern as a potential platform in ...
Silva, Catarina L.; Olival, Ana; Perestrelo, Rosa; Silva, Pedro; Tomás, Helena; Câmara, José S.: Breast cancer (BC) remains the second leading cause of death among women worldwide. An emerging approach based on the identification of endogenous metabolites (EMs) and the establishment of the metabolomic fingerprint of biological fluids constitutes a new frontier in medical diagnostics and a promising strategy to differentiate cancer patients from healthy individuals. In this work we aimed to establish the ...
Untargeted fingerprinting of cider volatiles from different geographical region...
Perestrelo, Rosa; Silva, Catarina L.; Silva, Pedro; Medina, Sonia; Pereira, Regina; Câmara, José S.The volatomic fingerprint of ciders produced in different geographical regions from Madeira Island was estab lished using headspace solid phase microextraction combined with gas chromatography mass spectrometry (HS SPME/GC–MS) in order to explore the effects of geographical region on the volatile pattern ciders in addition to identify potential molecular geographic markers. A total of 107 volatile organic compo...
Comparison of high-throughput microextraction techniques, MEPS and μ-SPEed, for...
Casado, Natalia; Perestrelo, Rosa; Silva, Catarina L.; Sierra, Isabel; Câmara, José S.In this study, two different high-throughput microextraction techniques, microextraction by packed sorbents (MEPS) and micro solid phase extraction (μ-SPEed®), were evaluated and compared, regarding the performance criteria, for the isolation of polyphenols from baby foods prior to their determination by ultrahigh pressure liquid chromatography (UHPLC). To achieve the best performance, influential parameters af...
Establishment of the volatile signature of wine-based aromatic vinegars subject...
Perestrelo, Rosa; Silva, Catarina L.; Silva, Pedro; Câmara, José S.The flavoring of vinegars with aromatic fruits and medicinal herbs is a practice with increasing trend mostly in countries with oenological tradition, resulting in a product of improved quality and consumer attractiveness. This study was directed towards the evaluation of the impact of the maceration process on the volatile signature of wine-based aromatic vinegars (WBAVs). The evaluation was performed using sol...
Impact of storage time and temperature on volatomic signature of Tinta Negra wi...
Perestrelo, R.; Silva, Catarina L.; Silva, Pedro; Câmara, J. S.The current study reports the effect of storage temperature, storage time and glucose content on the volatomic signature of Tinta Negra wines using liquid-liquid microextraction (LLME) combined with gas chromatography-ion trap mass spectrometry (GC-ITMS). A total of 65 volatile organic compounds (VOCs) were identified in Tinta Negra, of which only 14 appear during storage. Based on the results, the freshness an...