13 documents found, page 1 of 2

Antifungal activity of palmatine against strains of Candida spp. resistant to a...

The incidence of fungal infections has increased and it is necessary to seek new antifungals that also act against resistant strains. Palmatine is a protoberberine alkaloid noteworthy for its various pharmacological properties, including antifungal properties. The objective of this study was to evaluate the activity of palmatine against Candida spp. strains resistant to azole in planktonic cells and biofilm, an...

In vitro evaluation of the curcumin against fluconazole-resistant strains of Ca...

The isolates of Candida spp. and Cryptococcus neoformans were inhibited by curcumin, with different degrees of inhibition among species, with MICs ranging from 8-64 μg/mL. After exposure of the C. albicans strains to curcumin, it was observed a decrease in the number of viable cells and damage to cell membranes, the mitochondrial function of C. albicans cells appears to be affected after exposure to curcumin. O...

Chemical composition and antifungal In vitro and in silico, antioxidant, and an...

Ouratea fieldingiana (Gardner) Engl is popularly used for wound healing. This study describes the main chemical compounds present in extracts of O. fieldingiana and evaluates their biological potential by investigating antifungal, antioxidant, and anticholinesterase activities.The actionmechanismofmain antifungal compound was investigated bymolecular docking using the enzyme sterol 14- demethylase, CYP51, requi...

Registros de acidentes com animais peçonhentos (aranhas, escorpiões e serpernte...

Poisonings are common occurrences, which annually take to the population the demand for specialized health service, with regard to emergency rooms around the world including Braz il. In 2010 it was registered about 90,000 cases of poisoning by exposure to various agents including accidents with animals, but it is estimated that the actual number is almost double of cases, since many incidents are not reported. ...

Avaliação in vitro da atividade antifúngica da β-lapachona frente a cepas de Ca...

At the present time, a significant increase of opportunistic fungal infections is observed, mainly in immunocompromised patients. Candidiasis has been the most documented and are often associated with the formation of biofilms. Commercially available antifungal agents are restricted to a small number of drugs when compared to antibacterial agents. These facts, associated with the increase in the resistance freq...

Spirostanol glucosides from the leaves of Cestrum laevigatum L

Effects of piperonal nitro derivatives on candida species : antifungal activity...

Recently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural product...

Spirostanol glucosides from the leaves of Cestrum laevigatum L.

Two new steroidal saponins, (25R)-spirost-5-ene-3β,26β-diol 3-O-α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[(1 → 2)-α-l-rhamnopyranosyl]-β-d-glucopyranoside (1) and (25R)-spirost-6-ene-3β,5β-diol 3-O-α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[(1 → 2)-α-l-rhamnopyranosyl]-β-d-glucopyranoside (2), along with the known diosgenin 3-O-α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)...

Berberine antifungal activity in fluconazole-resistant pathogenic yeasts : acti...

The incidence of fungal infections and, in particular, the incidence of fungal antibiotic resistance, which is associated with bio- film formation, have significantly increased, contributing to morbidity and mortality. Thus, new therapeutic strategies need to be developed. In this context, natural products have emerged as a major source of possible antifungal agents. Berberine is a pro- toberberine-type isoquin...

Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole...

Candida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated...