4 documents found, page 1 of 1
Lipid-Polymeric Films: Composition, Production and Applications in Wound Healin...
Souto, Eliana B.; Yoshida, Cristiana M. P.; Leonardi, Gislaine R.; Cano, Amanda; Sanchez-Lopez, Elena; Zielińska, Aleksandra; Viseras, CésarThe use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually used in polymeric-based film formulations due to their plasticizing action, with a view to improving the mechanic...
Anti-tumor efficiency of Perillylalcohol/β-Cyclodextrin inclusion complexes in ...
Rezende, Allan A.; Santos, Rafael S.; Andrade, Luciana N.; Amaral, Ricardo G.; Pereira, Matheus M.; Bani, Cristiane; Chen, Mo; Priefer, RonnyThe low solubility and high volatility of perillyl alcohol (POH) compromise its bioavailability and potential use as chemotherapeutic drug. In this work, we have evaluated the anticancer activity of POH complexed with -cyclodextrin (-CD) using three complexation approaches. Molecular docking suggests the hydrogen-bond between POH and -cyclodextrin in molar proportion was 1:1. Thermal analysis and Fourier-transf...
β-cyclodextrin/isopentyl caffeate inclusion complex: synthesis, characterizatio...
Marques, Carine S. F.; Barreto, Nathalia S.; Oliveira, Simone S. C. de; Santos, André L. S.; Branquinha, Marta H.; Sousa, Damião P. de; Castro, MayaraIsopentyl caffeate (ICaf) is a bioactive ester widely distributed in nature. Our patented work has shown promising results of this molecule against Leishmania. However, ICaf shows poor solubility, which limits its usage in clinical settings. In this work, we have proposed the development of an inclusion complex of ICaf in -cyclodextrin (-CD), with the aim to improve the drug solubility, and thus, its bioavailab...
Alginate nanoparticles for drug delivery and targeting
Severino, Patricia; Silva, Classius F. da; Andrade, Luciana N.; Oliveira, Daniele de Lima; Campos, Joana; Souto, Eliana B.Nanotechnology refers to the control, manipulation, study and manufacture of structures and devices at the nanometer size range. The small size, customized surface, improved solubility and multi-functionality of nanoparticles will continue to create new biomedical applications, as nanoparticles allow to dominate stability, solubility and bioavailability, as well controlled release of drugs. The type of a nanopa...