7 documents found, page 1 of 1
Crises social sensing: longitudinal monitoring of social perceptions of systemi...
Gaspar, Rui; Domingos, Samuel; Toscano, Hugo; Filipe, Jessica; Leiras, Gisela; Raposo, Beatriz; Pereira, Cícero; Godinho, Cristina; Francisco, RitaMonitoring how different people – as ‘social sensors’ – evaluate and respond to crisis such as pandemics, allows tailoring crisis communication to the social perceptions of the situation, at different moments. To gather such evidence, we proposed a index of social perceptions of systemic risk (SPSR), as an indicator of a situational threat compromising risks to physical health, psychological health, the economy...
Crises social sensing: longitudinal monitoring of social perceptions of systemi...
Gaspar, Rui; Domingos, Samuel; Toscano, Hugo; Filipe, Jessica; Leiras, Gisela; Raposo, Beatriz; Pereira, Cicero Roberto; Godinho, CristinaMonitoring how different people – as ‘social sensors’ – evaluate and respond to crisis such as pandemics, allows tailoring crisis communication to the social perceptions of the situation, at different moments. To gather such evidence, we proposed a index of social perceptions of systemic risk (SPSR), as an indicator of a situational threat compromising risks to physical health, psychological health, the economy...
Scaling-up of aliviibrio fischeri recombinant L-Asparaginase production: develo...
Bento, Heitor; Paiva, Gabriela; Pedrolli, Danielle; Silva, Claudia; Tavares, Ana Paula; Santos-Ebinuma, ValériaAmong the several important steps in establishing a bioprocess, the definition of scaling-up parameters is one of the most important. The aim of this study was to evaluate the scaling up process of recombinant L-asparaginase production from orbital shaker to bioreactor, namely Stirred tank bioreactor (STR). Aliivibrio fischeri L-Asparaginase, expressed in Bacillus subtilis, was produced using Luria-Bertani (LB)...
Thermal kinetic analusis of aliviibrio fischeri recombinant L-Asparaginase
Bento, Heitor; Paiva, Gabriela; Pedrolli, Danielle; Carvalho, Pedro; Silva, Claudia; Tavares, Ana Paula; Santos-Ebinuma, ValériaThermal kinetic analysis is one of the main factors to establish a biopharmaceutical application. L-Asparaginase is an important enzyme for the pharmaceutical industry due to its application in the treatment of some lymphoid malignancies as acute lymphoblastic leukemia. Novel recombinant enzymes may be the solution in order to reduce or eliminate the side effects showed by the commercial preparations. The objec...
Intrahepatic Cholestasis due to Citrin Deficiency
Stilwell, Maria do Rosário; Silva, Claudia; Madureira, Inês; Bellegarde Machado, Rita; Nóbrega, Sara; Campos, António Pedro; Ferreira, Ana CristinaWe report a case of Neonatal Intrahepatic Cholestasis due to Citrin Deficiency in a 2-month-old female of Chinese descent who presented with jaundice and acholic stool. She had poor weight gain, axial hypotonia and large anterior fontanelle with no dysmorphia or hepatosplenomegaly. Laboratory findings showed cholestasis, elevated transaminases, hypoalbuminemia, prolonged prothrombin time, anaemia and galactosur...
Stroke rehabilitation and research: consideration of the role of the cortico-re...
Silva, Augusta; Vaughan-Graham, Julie; Silva, Claudia; Pinheiro De Sousa, Andreia Sofia; Cunha, Christine; Ferreira, Rosália; Barbosa, Pedro MacielA cerebrovascular accident, otherwise known as stroke, has the potential to damage multiple areas within the brain affecting descending motor control via a multitude of pathways resulting in a wide variety of movement problems. The cortico-reticulospinal system, one of the largest motor systems, is frequently affected, compromising its output, resulting in postural control deficits. The identification of clinic...
What is the role of apelin regarding cardiovascular risk and progression of ren...
Silva, Ana Paula; Fragoso, Andre; Silva, Claudia; Viegas, Carla; Tavares, Nelson; Guilherme, Patricia; Santos, Nelio; Rato, Fatima; Camacho, AnaAims. To evaluate the association of different apelin levels with cardiovascular mortality, hospitalization, renal function, and cardiovascular risk factors in type 2 diabetic patients with mild to moderate CKD. Methods. An observational, prospective study involving 150 patients divided into groups according to baseline apelin levels: 1 <= 98pg/mL, 2 = 98-328 pg/mL, and 3 >= 329 pg/mL. Baseline characteristics ...