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Diaphragmatic hernia repair porcine model to compare the performance of biodegr...

Scuglia, Marianna; Frazão, Laura P.; Miranda, Alice Augusta Macedo; Martins, Albino; Barbosa-Sequeira, Joana; Coimbra, Diana; Longatto, Adhemar

Published: 24 November 2023; Background Patch repair of congenital diaphragmatic hernia (CDH) using Gore-Tex® is associated with infection, adhesions, hernia recurrence, long-term musculoskeletal sequels and poor tissue regeneration. To overcome these limitations, the performance of two novel biodegradable membranes was tested to repair CDH in a growing pig model. Methods Twelve male pigs were randomly assigned...


Psychological morbidity in endometriosis: a couple’s study

Pereira, M. Graça; Ribeiro, Inês; Ferreira, Hélder; Osório, Filipa; Silva, Cristina Isabel Nogueira; Almeida, Ana C.

Endometriosis is a chronic gynecological disease that impacts more than 176 million women worldwide, having a strong impact on psychological morbidity. This study aimed to evaluate the contribution of psychological morbidity, in women with endometriosis, taking into consideration the duration of the couple’s relationship and the duration of the disease and also examined whether women’s sexual satisfaction had a...


Breast cancer post-surgical impact on women´s quality of life during chemothera...

Pereira, Marta; Moreira, Célia Sofia; Silva, Cristina Isabel Nogueira; Izdebski, Pawel; Pereira, M. Graça

Early View; Breast cancer is an important public health problem that is increasing in incidence, being a stressor with a negative impact on women's quality of life. This study is focused on the evaluation of temporal precursors (one month before) of women's quality of life undergoing chemotherapy, considering post-surgical personal, clinical, cognitive and neuropsychophysiological factors, according to the Tran...


Decellularized human chorion membrane as a novel biomaterial for tissue regener...

Frazão, Laura Passos Morgado Franco; Castro, Joana Vieira de; Silva, Cristina Isabel Nogueira; Neves, N. M.

Although some placenta-derived products are already used for tissue regeneration, the human chorion membrane (HCM) alone has been poorly explored. In fact, just one study uses decellularized HCM (dHCM) with native tissue architecture (i.e., without extracellular matrix (ECM) suspension creation) as a substrate for cell differentiation. The aim of this work is to fully characterize the dHCM for the presence and ...


Paternal uniparental disomy for chromosome 14: prenatal management

Silva, Joana Isabel Igreja da; Ribeiro, Barbara; Cadilhe, Alexandra; Silva, Cristina Isabel Nogueira

We present a case of a 34-year-old multiparous woman who had been diagnosed with a 14 weeks' gestation showing an abdominal wall bulge possibly representing an omphalocele, containing liver and intestinal loops, at her first-trimester ultrasound scan. At 16 weeks' gestation, an amniocentesis was performed and karyotype analysis revealed a balanced Robertsonian translocation between chromosomes 13 and 14 in a fe...


Use of etonogestrel implant beyond approved duration: prolonged contraceptive e...

Ribeiro, Bárbara C.; Silva, Cristina Isabel Nogueira; Afonso, Hermínia; Silva, Pedro O.; Reis, Isabel D.

The subdermal etonogestrel contraceptive implant has a current approved duration of 3 years. There is, however, recent and strong evidence of its effectiveness for 2 additional years during which no pregnancies were documented.; Background: The subdermal etonogestrel contraceptive implant has a current approved duration of 3 years. There is, however, recent and strong evidence of its effectiveness for 2 additio...


STATs in lung development: distinct early and late expression, growth modulatio...

Piairo, Paulina C.; Moura, Rute S.; Baptista, Maria João Ribeiro Leite; Correia-Pinto, Jorge; Silva, Cristina Isabel Nogueira

Congenital diaphragmatic hernia (CDH) is a life-threatening developmental anomaly, intrinsically combining severe pulmonary hypoplasia and hypertension. During development, signal transducers and activators of transcription (STAT) are utilized to elicit cell growth, differentiation, and survival.Background: Congenital diaphragmatic hernia (CDH) is a life-threatening developmental anomaly, intrinsically combinin...


Minilaparoscopic sigmoid vaginoplasty in Mayer-Rokitansky Syndrome

Silva, Cristina Isabel Nogueira; Bailez, Marcela; Silva, Pedro Oliveira da; Reis, Isabel; Correia-Pinto, Jorge

Mayer-Rokitansky-Küster-Hauser syndrome describes a vaginal and uterine agenesis, secondary to agenesis or hypoplasia of the Müllerian duct system. It presents an incidence of 1 in 4.500 females and it is the second most common cause of primary amenorrhea. Several techniques for functional neovagina creation have been described, namely different dilatation methods and different surgical techniques, however at p...


Pneumotórax catamenial: uma apresentação atípica de endometriose

Miranda, Alexandra Sofia Lopes; Silva, Cristina Isabel Nogueira; Abreu, Catia Lia; Cabrita, João Pedro Jordão Bentes; Pena, Domingos Jardim da

A endometriose torácica representa uma manifestação rara de endometriose, devendo ser considerada nas mulheres em idade reprodutiva que se apresentam com dor torácica, pneumotórax, hemotórax ou hemoptises coincidentes com a menstruação. Reportamos o caso clínico de uma mulher de 38 anos com dor torácica repetitiva e progressiva durante o cataménio, acompanhada de dispneia moderada e tosse não produtiva, com 4 a...


Minilaparoscopic versus conventional laparoscopic sacrocolpopexy: a comparative...

Ferreira, Hélder; Ferreira, Carlos; Silva, Cristina Isabel Nogueira; Tomé, António; Guimarães, Serafim; Correia-Pinto, Jorge

Introduction and Aims: We aim to compare clinical and surgical outcomes between minilaparoscopic sacrocolpopexy (MLSC) and conventional laparoscopic sacrocolpopexy (LSC). As far as we know, no comparative study exists between these two minimal invasive procedures to correct vaginal prolapse. Design and Setting: An observational and comparative study with 20 individuals submitted to vaginal vault prolapse correc...


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