2 documents found, page 1 of 1
Unexpected Therapeutic Effects of Common Drugs: Lessons from 15 Years of Drug R...
Gonçalves, Jorge Manuel Moreira; Quintas, Clara; Silva, Dany; Queiroz, Glória; Fresco, PaulaDrug repurposing (DR) is one of the expressions that has been used to translate the process of discovering new therapeutic uses for drugs already approved for other clinical indications. The concept was presented 15 years ago. Initially, the intention was to shorten the pharmaceutical research and development (R&D) process and thereby reduce the costs and risks for the pharmaceutical industry to bring new m...
β-Adrenoceptor Activation in Breast MCF-10A Cells Induces a Pattern of Catechol...
Amaro, Filipa; Silva, Dany; Reguengo, Henrique; Oliveira, José Carlos; Quintas, Clara; Vale, Nuno; Gonçalves, Jorge; Fresco, PaulaAdrenaline, which participates in the neuroendocrine response that occurs during stress and perimenopause, may be tumorigenic. This exploratory study aimed at investigating whether non-tumorigenic and tumorigenic human breast epithelial cell lines are able to synthesize adrenaline. The study was carried out in non-tumorigenic (MCF-10A) and tumorigenic (MCF-7) human breast cell lines. Expression of enzymes invol...