Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology. Objective: To examine the association between depressive symptoms and amyloid pathology and its dependency on age, sex, education...
Background: The development and clinical use of biomarkers has dramatically changed the framework of Alzheimer’s disease (AD) management, allowing the diagnosis at the mild cognitive impairment (MCI) stage. In 2015 we compared the prevalence and prognosis of AD at the MCI stage according to different criteria available at that time, and we found that the National Institute of Aging-Alzheimer Association (NIA-AA...
Background:The concept of amnestic mild cognitive impairment (aMCI) was developed to identify patients at an initial stage of Alzheimer's disease (AD). However, some patients with aMCI do not present biomarkers of amyloid pathology or neuronal injury.Objective:To know the natural history of amyloid-negative and neurodegeneration-negative patients with aMCI, namely to ascertain: 1) whether these patients remain ...
O objetivo da campanha PELAGO23 foi determinar a distribuição espacial da sardinha, biqueirão e cavala, e estimar a sua abundância e biomassa, assim como avaliar a estrutura da comunidade de peixes pelágicos, a distribuição e abundância de ovos e larvas, o censo de aves e mamíferos e a caracterização das condições ambientais na plataforma continental portuguesa e Baia de Cádis. A campanha decorreu de 15 de març...
A campanha PELAGO22 decorreu do dia 01 ao 31 de março de 2022, e foi subdividida em duas partes. A primeira, de 01 a 09 de março, foi realizada a bordo do Navio de Investigação Miguel Oliver e a segunda, de 12 a 31 de março, no Navio de Investigação Vizconde de Eza, num total de 24 dias de trabalho no mar. A necessidade de troca de navio, entre as duas partes, deveu-se ao significativo agravamento de falhas elé...
Introdução: A gamificação tem proliferado como uma estratégia auspiciosa perante desafios empresariais contemporâneos, nomeadamente a alienação da força de trabalho. Todavia, pouco se sabe acerca de como a gamificação transforma o comportamento humano, sobretudo na área comercial. Objetivos: Pretende-se estudar o impacto da gamificação na motivação e no engagement dos vendedores, identificando os elementos de j...
Subjective Memory Complaints (SMC) along with cognitive deficits are frequently observed in patients with Major Depressive Disorder (MDD). The relationship between SMC and objective memory performance in patients with MDD was evaluated, in comparison with patients with Mild Cognitive Impairment due to Alzheimer's Disease (MCI-AD) and healthy controls (HC).
Background: Subjective Memory Complaints (SMC) along with cognitive deficits are frequently observed in patients with Major Depressive Disorder (MDD). The relationship between SMC and objective memory performance in patients with MDD was evaluated, in comparison with patients with Mild Cognitive Impairment due to Alzheimer’s Disease (MCI-AD) and healthy controls (HC). Methods: Patients with MDD (n = 47), MCI-AD...
Patients diagnosed with amnestic mild cognitive impairment (aMCI) are at high risk of progressing to dementia. It became possible, through the use of biomarkers, to diagnose those patients with aMCI who have Alzheimer's disease. However, it is presently unfeasible that all patients undergo biomarker testing. Since neuropsychological testing is required to make a formal diagnosis of aMCI, it would be interesting...