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Neuropsychological contribution to predict conversion to dementia in patients w...
Silva, Dina Lúcia Gomes da; Cardoso, Sandra; Guerreiro, Manuela; Marôco, J. P.; Mendes, Tiago; Alves, Luísa; Nogueira, Joana Maia; Baldeiras, InesDiagnosis of Alzheimer's disease (AD) confirmed by biomarkers allows the patient to make important life decisions. However, doubt about the fleetness of symptoms progression and future cognitive decline remains. Neuropsychological measures were extensively studied in prediction of time to conversion to dementia for mild cognitive impairment (MCI) patients in the absence of biomarker information. Similar neurops...
Mental time travel in mild cognitive impairment
Coelho, Sara; Guerreiro, Manuela; Chester, Catarina; Silva, Dina Lúcia Gomes da; Marôco, J. P.; Paglieri, Fabio; Mendonça, Alexandre deIntroduction: Mental Time Travel (MTT) is the people's ability to remember themselves in the past and to imagine themselves in the future, and influence important life domains such as making decisions and planning future actions. It is widely recognized that patients with aMCI have deficits in episodic memory, but they also show impairments in semantic memory. It has been controversial whether MTT tasks are dis...
Neuropsychological Predictors of long-term (10 Years) Mild Cognitive Impairment...
Alves, Luísa; Cardoso, Sandra; Marôco, J. P.; De Mendonça, Alexandre; Guerreiro, Manuela; Silva, Dina Lúcia Gomes daAlthough the diagnosis of mild cognitive impairment (MCI) corresponds to a condition likely to progress to dementia, essentially Alzheimer's disease, longitudinal studies have shown that some patients may not convert to dementia and maintain the diagnosis of MCI even after many years.
Delay discounting in mild cognitive impairment
Coelho, Sara; Guerreiro, Manuela; Chester, Catarina Carapeto da Silva; Silva, Dina Lúcia Gomes da; Maroco, João; Paglieri, Fabio; Mendonça, Alexandre deIntroduction : Patients with mild cognitive impairme nt (MCI) may make suboptimal decisions particularly in complex situations, and thi s could be due to temporal discounting, the tendency to prefer immediate rewards over delayed but larger rewards. The present study proposes to evaluate intertemporal prefere nces in MCI patients as compared to healthy controls. Method : Fifty-five patients with MCI and 57 h ea...
Time perception in mild cognitive impairment: Interval length and subjective pa...
Coelho, Sara; Guerreiro, Manuela; Chester, Catarina Carapeto da Silva; Silva, Dina Lúcia Gomes da; Maroco, João; Coelho, Miguel; Paglieri, FabioObjectives: Patients with mild cognitive impairment (MCI) may have difficulties in time perception, which in turn might contribute to some of their symptoms, especially memory deficits. The aim of this study was to evaluate perception of interval length and subjective passage of time in MCI patients as compared to healthy controls. Methods: Fifty-five MCI patients and 57 healthy controls underwent an experiment...
Comparison of four verbal memory tests for the diagnosis and predictive value o...
Silva, Dina Lúcia Gomes da; Guerreiro, Manuela; Maroco, João; Santana, Isabel; Rodrigues, Ana; Marques, José Bravo; Mendonça, Alexandre deBackground: Mild cognitive impairment (MCI) is considered to be an early stage of a neurodegenerative disorder, particularly Alzheimer’s disease, and the clinical diagnosis requires the objective demonstration of cognitive deficits. The aim of the present study was to evaluate the predictive value of MCI for the conversion to dementia when using four different verbal memory tests (Logical Memory, LM; California...
Prediction of dementia patients: A comparative approach using parametric vs. no...
Maroco, João; Silva, Dina Lúcia Gomes da; Guerreiro, Manuela; Mendonça, Alexandre de; Santana, IsabelIn this paper, we report a comparison study of 7 non parametric classifiers (Multilayer perceptron Neural Networks, Radial Basis Function Neural Networks, SupportVectorMachines, CART, CHAID and QUEST Classification trees and Random Forests) as compared to Linear Discriminant Analysis, Quadratic Discriminant Analysis and Logistic Regression tested in a real data application of mild cognitive impaired elderly pat...
Memory complaints associated with seeking clinical care
Pires, Carolina; Silva, Dina Lúcia Gomes da; Maroco, João; Ginó, Sandra; Mendes, Tiago; Schmand, Ben A.; Guerreiro, Manuela; Mendonça, Alexandre deDiagnosis of mild cognitive impairment relies on the presence of memory complaints. However, memory complaints are very frequent in healthy people. The objective of this study was to determine the severity and type of memory difficulties presented by elderly patients who seek for clinical help, as compared to the memory difficulties reported by subjects in the community. Assessment of subjective memory complain...
Data mining methods in the prediction of dementia: A real-data comparison of th...
Maroco, João Lúcia Gomes da; Silva, Dina Lúcia Gomes da; Rodrigues, Ana; Guerreiro, Manuela; Santana, Isabel; Mendonça, Alexandre deBackground: Dementia and cognitive impairment associated with aging are a major medical and social concern. Neuropsychological testing is a key element in the diagnostic procedures of Mild Cognitive Impairment (MCI), but has presently a limited value in the prediction of progression to dementia. We advance the hypothesis that newer statistical classification methods derived from data mining and machine learning...
Cognitive deficits in middle-aged and older adults with bipolar disorder and co...
Silva, Dina Lúcia Gomes da; Santana, Isabel; Couto, Frederico Simões do; Maroco, João; Guerreiro, Manuela; Mendonça, Alexandre deObjective Cognitive impairment has been reported in elderly bipolar disorder (BD) patients, however, few studies have evaluated middle-aged and older BD patients using standardized cognitive assessments and none (to our knowledge) analysed middle-aged and older BD patients with recent cognitive complaints. The main objective of this study is to characterize the cognitive deficits of middle-aged and older patien...