10 documents found, page 1 of 1
Osteogenic differentiation triggered by intracellular magnetoelectric stimulati...
Mendes, Maria C.; Martins, Elisa A.G.; Chernozem, Roman V.; Chernozem, Polina V.; Custódio, Catarina C.; Surmenev, Roman A.; Kholkin, Andrei L.Magnetoelectric nanoparticles (MENPs), combining a magnetostrictive core with a piezoelectric shell, offer a promising route for remote-controlled biomedical applications by converting external magnetic fields into electric cues. However, the clinical translation of these materials remains limited due to the toxicity of high-performance piezoelectric materials, which typically contain lead. Previously, we devel...
Human chorionic membrane-derived tunable hydrogels for vascular tissue engineer...
Martins, Elisa A. G.; Deus, Inês A.; Gomes, Maria C.; Silva, Ana S.; Mano, João F.; Custódio, Catarina A.One of the foremost targets in the advancement of biomaterials to engineer vascularized tissues is not only to replicate the composition of the intended tissue but also to create thicker structures incorporating a vascular network for adequate nutrients and oxygen supply. For the first time, to the best of current knowledge, a clinically relevant biomaterial is developed, demonstrating that hydrogels made from ...
Magneto-enzymatic microgels for precise hydrogel sculpturing
Mendes, Maria C.; Pereira, João A.; Silva, Ana S.; Mano, João F.The inclusion of hollow channels in tissue-engineered hydrogels is crucial for mimicking the natural physiological conditions and facilitating the delivery of nutrients and oxygen to cells. Although bio-fabrication techniques provide diverse strategies to create these channels, many require sophisticated equipment and time-consuming protocols. Herein, collagenase, a degrading agent for methacrylated gelatin hyd...
Magnetic-based strategies for regenerative medicine and tissue engineering
Santos, Lúcia F.; Silva, Ana S.; Mano, João F.The fabrication of biological substitutes to repair, replace, or enhance tissue- and organ-level functions is a long-sought goal of tissue engineering (TE). However, the clinical translation of TE is hindered by several challenges, including the lack of suitable mechanical, chemical, and biological properties in one biomaterial, and the inability to generate large, vascularized tissues with a complex structure ...
Adjustable conduits for guided peripheral nerve regeneration prepared from bi-z...
Millán, Diana; Jiménez, Ronald A.; Nieto, Luis E.; Poveda, Ivan Y.; Torres, Maria A.; Silva, Ana S.; Ospina, Luis F.; Mano, João F.Shortness of donor nerves has led to the development of nerve conduits that connect sectioned peripheral nerve stumps and help to prevent the formation of neuromas. Often, the standard diameters of these devices cannot be adapted at the time of surgery to the diameter of the nerve injured. In this work, scaffolds were developed to form filled nerve conduits with an inner matrix with unidirectional channels cove...
Multi-layer pre-vascularized magnetic cell sheets for bone regeneration
Silva, Ana S.; Santos, Lúcia F.; Mendes, Maria C.; Mano, João F.The lack of effective strategies to produce vascularized 3D bone transplants in vitro, hampers the development of thick-constructed bone, limiting the translational of lab-based engineered system to clinical practices. Cell sheet (CS) engineering techniques provide an excellent microenvironment for vascularization since the technique can maintain the intact cell matrix, crucial for angiogenesis. In an attempt t...
Bisphenol A as result of its migration from epoxy resins
Vilarinho, Fernanda; Vaz, M.Fátima; Silva, Ana S.Materials and articles intended to contact with food (Food Contact Materials; FCMs), including food packaging, are not generally realize to be a chemical health threat when compared to pesticides, veterinary drugs, heavy metals or mycotoxins that are well recognised food contaminants arising from agricultural practices, the environment or improper food storage. However, within the last decade, it has become acc...
Low-cost wearable data acquisition for stroke rehabilitation: A proof-of-concep...
Salazar, Antonio J.; Silva, Ana S.; Silva, Cláudia; Borges, Carla M.; Correia, Miguel V.; Santos, Rubim; Vilas-Boas, Joao P.Background: An increasingly aging society and consequently rising number of patients with poststroke-related neurological dysfunctions are forcing the rehabilitation field to adapt to ever-growing demands. Although clinical reasoning within rehabilitation is dependent on patient movement performance analysis, current strategies for monitoring rehabilitation progress are based on subjective time-consuming assess...
Compensatory movement detection through inertial sensor positioning for post-st...
Borges, Carla M.; Silva, Cláudia; Salazar, António J.; Silva, Ana S.; Correia, Miguel V.; Santos, Rubim; Vilas-Boas, João P.An increasing ageing society and consequently rising number of post-stroke related neurological dysfunction patients are forcing the rehabilitation field to adapt to ever-growing demands. In parallel, an unprecedented number of research efforts and technological solutions meant for human monitoring are continuously influencing traditional methodologies, causing paradigm shifts; extending the therapist patient d...
Modulation of erythrocyte hemorheological properties by band 3 phosphorylation ...
Saldanha, Carlota; Silva, Ana S.; Gonçalves, Sónia; Martins-Silva, JoãoThe objective of the present work was to study the effects of erythrocyte proteins phosphorylation in erythrocyte aggregation and deformability. Human whole blood samples were incubated in vitro in absent and in presence of the phosphorylation/dephosphorilation band 3 inhibitors and also with adenylyl cyclase, guanylate cyclase and PI3K inhibitors and the erythrocyte aggregation index (EAI) and deformability we...