9 documents found, page 1 of 1
Predicting bladder cancer risk in patients with hematuria. A single-centre retr...
Jarimba, Roberto; Quaresma, Vasco; Pedroso Lima, João; Eliseu, Miguel; Silva, Edgar Tavares da; Moreira, Pedro; Figueiredo, ArnaldoIntroduction: The presence of blood in the urine should be promptly investigated to rule out urological malignancies, bladder cancer being the most frequent. Given its frequency among general population and the lack of unlimited health resources in an era of cost-effectiveness, it is important to prioritize patients with higher risk of malignancy. Objectives: To identify predictive factors of bladder cancer amo...
Novel hormonal agents for metastatic Castration-Resistant Prostate Cancer: comp...
Jarimba, Roberto Saldanha; Eliseu, Miguel Nobre; Pedroso Lima, João; Quaresma, Vasco; Moreira, Pedro; Nunes, Pedro Coelho; Silva, Edgar Tavares daProstate cancer is the most common cancer in men, accounting for 15% of all diagnosed cancers and is the sixth leading cause of cancerrelated deaths amongst men worldwide. Abiraterone and enzalutamide were the first two novel hormonal agents approved for the treatment of metastatic prostate cancer but there is a lack of quality evidence regarding which is associated with better outcomes and who would benefit th...
[68Ga]Ga-PSMA-11 PET-CT: Local preliminary experience in prostate cancer bioche...
Carvalho, João; Nunes, Pedro; Silva, Edgar Tavares da; Silva, Rodolfo; Lima, João; Quaresma, Vasco; Figueiredo, ArnaldoObjectives: Clinical approach of prostate cancer (PCa) biochemical recurrence (BCR) is an ever-changing topic. Prostate-specific membrane antigen positron emission tomography ([68Ga]Ga-PSMA-11 PET-CTPSMA PET-CT) has shown good potential in this field. The aim is to evaluate PSMA PET-CT detection rate in PCa BCR and assess its impact on clinical outcome. Material and methods: Out of 319 patients with PCa who und...
Cold Atmospheric Plasma, a Novel Approach against Bladder Cancer, with Higher S...
Silva, Edgar Tavares da; Pereira, Eurico; Pires, Ana S.; Neves, Ana Rita M.; Guilherme, Catarina Braz; Marques, Inês A.; Abrantes, Ana M.Antitumor therapies based on Cold Atmospheric Plasma (CAP) are an emerging medical field. In this work, we evaluated CAP effects on bladder cancer. Two bladder cancer cell lines were used, HT-1376 (stage III) and TCCSUP (stage IV). Cell proliferation assays were performed evaluating metabolic activity (MTT assay) and protein content (SRB assay). Cell viability, cell cycle, and mitochondrial membrane potential (...
De novo colorectal cancer after liver and kidney transplantation–Microenvironme...
Oliveira, Rui Caetano; Silva, Edgar Tavares da; Abrantes, Ana Margarida; Antunes, Hugo; Teixeira, Paulo; Gomes, Ana; Martins, Ricardo; Furtado, EmanuelColorectal cancer (CRC) is a major health burden and may arise as a complication of solid organ transplantation. Our study aimed to assess the incidence of the CRC in kidney and liver transplanted patients at a tertiary and reference center and to describe their clinical and pathological features. Twelve patients, 10 men and two women, with a mean age of 60 years, composed our cohort, ten of them submitted to C...
Impact of Positive Surgical Margins After Partial Nephrectomy
Carvalho, João André Mendes; Nunes, Pedro; Silva, Edgar Tavares da; Parada, Belmiro; Jarimba, Roberto; Moreira, Pedro; Retroz, Edson; Caetano, RuiBackground: The impact of positive surgical margins (PSMs) after partial nephrectomy (PN) is controversial. Objective: To evaluate the risk factors for a PSM and its impact on overall survival. Design, setting, and participants: This is a retrospective study of 388 patients were submitted to PN between November 2005 and December 2016 in a single centre. Two groups were created: PSM and negative surgical margin ...
Statins Prevent Biochemical Recurrence of Prostate Cancer After Radical Prostat...
Jarimba, Roberto; Lima, João Pedroso; Eliseu, Miguel; Carvalho, João; Antunes, Hugo; Silva, Edgar Tavares da; Moreira, Pedro; Figueiredo, ArnaldoIntroduction: Prostate cancer is the most commonly diagnosed cancer in men. Radical prostatectomy is a potentially curative alternative for localized disease, although a significant percentage of these patients will suffer a biochemical recurrence with associated mortality. A wide spectrum of anticancer properties of statins has been demonstrated and the role of these drugs in prevention and treatment of other ...
Transumbilical laparoendoscopic single-site adrenalectomy: A feasible and safe ...
Carvalho, João André; Nunes, Pedro Tiago; Antunes, Hugo; Parada, Belmiro; Retroz, Edson; Silva, Edgar Tavares da; Paiva, IsabelObjectives: Standard multi-port laparoscopic adrenalectomy (LA) is considered the gold standard for benign adrenal tumors. Single-site LA has been proposed as a feasible and safe alternative because of lower invasiveness, improved cosmetics, less pain and shorter hospital stay. The objective was to evaluate and compare results of single-site transumbilical laparoendoscopic adrenalectomy with standard LA for adr...
Diabetes mellitus and prostate cancer metabolism: Is there a relationship?
Antunes, Hugo Pontes; Teixo, Ricardo; Carvalho, João André; Eliseu, Miguel; Marques, Inês; Mamede, Ana; Neves, Rita; Oliveira, RuiObjective: Our aim was to evaluate the effects of glucose levels and diabetes mellitus in prostate cancer (PCa) biology. Materials and methods: Two PCa cell lines (LNCap and PC3) were cultured in RPMI medium with different glucose concentrations [5mM (LG) and 25mM (HG)]. Expressions of androgen receptor, Her2/neu and glucose transporters (GLUT1, 3, 5 and 12) were evaluated by flow cytometry. Proliferation rate ...