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Performance of recombinant chimeric proteins in the serological diagnosis of Tr...
Leony, Leonardo Maia; Freitas, Natália Erdens Maron de; Del-Rei, Rodrigo Pimenta; Carneiro, Cláudia Martins; Reis, Alexandre Barbosa; Jansen, Ana MariaBackground: Dogs are considered sentinels in areas of Trypanosoma cruzi transmission risk to humans. ELISA is generally the method of choice for diagnosing T. cruzi exposure in dogs, but its performance substantially depends on the antigenic matrix employed. In previous studies, our group has developed four chimeric antigens (IBMP-8.1, 8.2, 8.3, and 8.4) and evaluated their potential for diagnosing T. cruzi exp...
A multicentric evaluation of the recombinant Leishmania infantum antigen-based ...
Fraga, Deborah Bittencourt Mothé; Silva, Edimilson Domingos da; Pacheco, Luciano Vasconcellos; Borja, Lairton Souza; Oliveira, Isaac Queiroz deBackground: Visceral leishmaniasis (VL) is a serious public health challenge in Brazil and dogs are considered to be the main urban reservoir of the causative agent. The culling of animals to control VL in some countries makes the accurate diagnosis of canine VL (CVL) essential. Recombinant antigens rLci1A and rLci2B were selected from a cDNA library of Leishmania infantum amastigotes due to their strong potent...