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Menthol-based deep eutectic systems as antimicrobial and anti-inflammatory agen...
Oliveira, F.; Silva, Eduardo Alexandre Pereira; Matias, A.; Silva, J. M.; Reis, R. L.; Duarte, A. R. C.Effective antimicrobial treatment has been identified as a serious and unmet medical need. Herein, we present a strategy based on deep eutectic systems (DES) to overcome current limitations, answering the need not only to effectively kill bacterial agents but also to avoid their adhesion and proliferation, which is associated with biofilm formation and have a crucial impact on bacterial virulence. To achieve su...
Surface functionalization of ureteral stents-based polyurethane: engineering an...
Ecevit, Kardelen; Silva, Eduardo Alexandre Pereira; Rodrigues, Luísa Cidália Guimarães; Aroso, Ivo; Barros, Alexandre A.; Silva, Joana M.; Reis, R. L.Bacterial colonization of polyurethane (PU) ureteral stents usually leads to severe and challenging clinical complications. As such, there is an increasing demand for an effective response to this unmet medical challenge. In this study, we offer a strategy based on the functionalization of PU stents with chitosan-fatty acid (CS-FA) derivatives to prevent bacterial colonization. Three different fatty acids (FAs)...
Optimal design of THEDES based on Perillyl Alcohol and Ibuprofen
Silva, Eduardo Alexandre Pereira; Oliveira, F.; Silva, Joana M.; Matias, A.; Reis, R. L.; Duarte, Ana Rita C.Therapeutic deep eutectic systems (THEDES) have dramatically expanded their popularity in the pharmaceutical field due to their ability to increase active pharmaceutical ingredients (APIs) bioavailability. However, their biological performance has not yet been carefully scrutinized. Herein, THEDES based on the binary mixture of perillyl alcohol (POH) and ibuprofen (IBU) were prepared using different molar ratio...