3 documents found, page 1 of 1
Involvement of intrinsic mitochondrial pathway in neosergeolide-induced apoptos...
Coelho Cavalcanti, Bruno; Costa, Patrícia Marçal da; Carvalho, Adriana Andrade Carvalho; Rodrigues, Francisco Augusto Rocha Santos; Amorim, Rodrigo C.N.Context: Quassinoids are biologically active secondary metabolites found exclusively in the Simaroubaceae family of plants. These compounds generally present important biological properties, including cytotoxic and antitumor properties. Objective: In the present study, the cytotoxic effects of neosergeolide, a quassinoid isolated from Picrolemma sprucei Hook. f., were evaluated in human promyelocytic leukemia c...
Biological activity of neosergeolide and isobrucein B (and two semi-synthetic d...
Silva, Ellen Cristina Costa; Coelho Cavalcanti, Bruno; Amorim, Rodrigo C.N.; Lucena, Jorcilene F.; Quadros, Dulcimar S.; Tadei, Wanderli PedroIn the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). These compounds were evaluated for general toxicity toward the brine shrimp species Artemia franciscana, cytotoxicity...
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazon...
Andrade Neto, Valter Ferreira de; Pohlit, Adrian Martin; Pinto, Ana Cristina da Silva; Silva, Ellen Cristina Costa; Nogueira, Karla LagosIn the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more activ...