5 documents found, page 1 of 1
22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma ...
Aranha, Elenn Suzany Pereira; Portilho, Adrhyann Jullyanne de Sousa; Sousa, Leilane Bentes de; Silva, Emerson Lucena da; Mesquita, Felipe PantojaEthnopharmacological relevance: 22β-hydroxytingenone (22-HTG) is a quinonemethide triterpene isolated from Salacia impressifolia (Miers) A. C. Smith (family Celastraceae), which has been used in traditional medicine to treat a variety of diseases, including dengue, renal infections, rheumatism and cancer. However, the anticancer effects of 22-HTG and the underlying molecular mechanisms in melanoma cells have no...
Kinase inhibition in relapsed/refractory leukemia and lymphoma settings: recent...
Machado, Caio Bezerra; Pessoa, Flávia Melo Cunha de Pinho; Silva, Emerson Lucena da; Pantoja, Laudreísa da Costa; Ribeiro, Rodrigo MonteiroCancer is still a major barrier to life expectancy increase worldwide, and hematologic neoplasms represent a relevant percentage of cancer incidence rates. Tumor dependence of continuous proliferative signals mediated through protein kinases overexpression instigated increased strategies of kinase inhibition in the oncologic practice over the last couple decades, and in this review, we focused our discussion on...
Análise in silico da farmacocinética e farmacodinâmica do composto benzotiazóli...
Mesquita, Felipe Pantoja; Lima, Luina Benevides; Daniel, Julio Paulino; Portilho, Adrhyann Jullyanne de Sousa; Oliveira, Lais Lacerda Brasil deGastric adenocarcinoma has high incidence and mortality rates worldwide. The aim of this study was to evaluate the antitumor activity of benzothiazole AFN01 against ACP03 gastric adenocarcinoma cell line. Furthermore, computational prediction of the pharmacokinetics and pharmacodynamics of this molecule and the molecular docking with the relevant pharmacological target found were performed. The MTT assay was pe...
O uso de linhagens leucêmicas e a sua importância na oncologia experimental
Sales, Lívia de Oliveira; Nogueira, Beatriz Maria Dias; Silva, Emerson Lucena da; Moraes, Maria Elisabete Amaral de; Montenegro, Raquel CarvalhoExperimental oncology is based on a model of study through cell culture, a technique frequently used for the study of cancer biology and for tests of new anticancer therapies. This model provides an appropriate system for researching the effects of drugs and toxic compounds on cells, mutagenesis and carcinogenesis, in drug screening and development. In addition the cell lines allows consistent and reproducible ...
Mebendazole induces apoptosis via C-MYC inactivation in malignant ascites cell ...
Pinto, Laine Celestino; Mesquita, Felipe Pantoja; Soares, Bruno Moreira; Silva, Emerson Lucena da; Puty, Bruna; Oliveira, Edivaldo Herculano Correa deFederal University of Par?. Biological Science Institute. Laboratory of Experimental Neuropathology. Bel?m, PA, Brazil.; Federal University of Cear?. Drug Research and Development Center. Laboratory of Pharmacogenetics. Fortaleza, CE, Brazil.; Federal University of Par?. Biological Science Institute. Laboratory of Human Cytogenetics. Bel?m, PA, Brazil.; Federal University of Cear?. Drug Research and Development...