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A contemporary systematic review on deterministic numerical simulations of ligh...

Fernandes, Filipa Gracinda Silva; Sousa, Nuno; Silva, Filipe Samuel; Carvalho, Óscar Samuel Novais; Catarino, Susana Oliveira

Understanding how light interacts with the head’s tissues is relevant for several biomedical applications. Since in vivo studies involve ethical considerations, numerical simulations have become a recognised alternative method for studying light propagation in biological tissue. Although Monte Carlo methods are the gold standard for these studies, deterministic simulations are becoming more common due to their ...


Engineering graphene quantum dots via laser ablation for epinephrine sensing

Ricardo, Philipi Cavalcante; Vanoni, Caio Raphael; Padrão, Jorge; Zille, Andrea; Satulu, Veronica; Mitu, Bogdana; Pereira, Mário R.

In this study, we report a sustainable strategy for the synthesis of functionalized graphene quantum dots (GQDs) via pulsed laser ablation in liquid (PLAL), employing sodium-based salts (NaCl, NaNO3, and Na2SO3) as functional sources to introduce chlorine, nitrogen, and sulfur, respectively. This single-step green synthesis yields highly pure GQDs with tunable optical and electrochemical properties. Comprehensi...


Ti6Al4V-Ag 3D Multi-Materials fabricated by Laser Powder Bed Fusion for Biomedi...

Rodrigues, Flávio Gabriel Silva; Bartolomeu, Flávio; Silva, Filipe Samuel; Madeira, Sara Cristina Soares

Biomedical implants often face two major challenges after implantation: post-surgical infections and poor osteointegration. Recent advances suggest that applying electrical current is a promising strategy to address both complications. In this context, a new implant design is proposed that combines the intrinsic properties of Ti6Al4V and Ag(silver). Ti6Al4V, a titanium alloy, is widely used for implants because...


In vitro evaluation of periodontal fibroblast response to bioinspired porous ch...

Ribeiro, Joana; Proença, Manuela; Rodrigues, Flávio Gabriel Silva; Chaves, Diego Morais; Ferreira, Diana P.; Rimondini, Lia; Gasik, Michael

Customized implant approaches are emerging to meet specific patient needs while minimizing complications. Despite advances in osseointegrated implants, issues such as excessive bone loading, bacterial infiltration, peri-implantitis, and bone loss persist. Bioinspired designs with customized geometries and surfaces that promote fibrointegration, inspired by the periodontal ligament of a natural tooth, are increa...


Manufacturing accuracy of unsupported inverted U-Type thin-walls in LPBF: Surfa...

Dias, Juliana Marques; Gasik, Michael; Bartolomeu, Flávio; Silva, Filipe Samuel; Miranda, Georgina

Additive Manufacturing (AM) has revolutionized orthopaedic implant development by enabling the creation of porous, patient-specific structures that enhance bone-implant integration. However, despite continuous advances, over 10% of orthopaedic implants still fail due to poor osteointegration and bone resorption. As younger and more active patients increasingly require joint replacements, developing durable, inf...


Gold nanoparticles synthesized by laser ablation in saline medium: an assessmen...

Ricardo, Philipi Cavalcante; Vanoni, Caio Raphael; Piotrowski, Maurício Jeomar; COSTA, DANIEL COUTINHO; Padrão, Jorge; Zille, Andrea; Satulu, Veronica

Gold nanoparticles (AuNPs) produced via pulsed laser ablation in liquids (PLAL) offer significant advantages due to their high purity and absence of ligands. However, their long-term stability is often compromised by aggregation and colloidal destabilization, which are not yet fully understood. This study investigates the influence of different saline agents (NaCl, NaNO3, Na2SO3) and storage conditions on the s...


Electroactive coatings on laser-textured titanium-based substrates for an impro...

Silva, Pedro F.; Crispim, Tiago R.; Carvalho, Óscar Samuel Novais; Fernandes, Mariana P.; Moreira, Joana Catarina Dias; Oliveira, Sofia

The growing aging population and the rising prevalence of osteodegenerative diseases indicate an increasing demand for orthopaedic implants worldwide. One of the main causes of failure of these implants are linked to nosocomial infections, and traditional approaches, such as antibiotics, are becoming limited by the development of resistance. In this work, titanium (Ti6Al4V) samples, typically used in orthopaedi...


Tratar dentes hipomineralizados (MIH) com coroas flexíveis ultrafinas para uma ...

Silva, Filipe Samuel; Rodrigues, Flávio Gabriel Silva; Arieira, Ana Filipa Amorim; Madeira, Sara Cristina Soares; Pinto, João Pedro Figueiredo

Esta comunicação irá apresentar coroas de cor próxima da dos dentes, ultrafinas, flexíveis, personalizadas, ideais para dentes hipomineralizados em crianças. O uso destas coroas não requer qualquer preparação dentária, anestesia, brocagem, não provocando qualquer dor, e garantindo uma proteção dentária prolongada. Este tratamento é o mais adequado para crianças assim como para dentistas pediátricos. Além disso,...


Experimental validation of time-explicit ultrasound propagation models with sou...

Fernandes, Nuno Alexandre Tavares Campos; Sharma, Shivam; Arieira, Ana Filipa Amorim; Hinckel, Betina; Silva, Filipe Samuel

Ultrasonic wave attenuation in biological tissues arises from complex interactions between mechanical, structural, and fluidic properties, making it essential to identify dominant mechanisms for accurate simulation and device design. This work introduces a novel integration of experimentally measured tissue parameters into time-explicit nonlinear acoustic wave simulations, in which the equations are directly so...


Models for light propagation in the head: trends and implementation of Finite E...

Fernandes, Filipa Gracinda Silva; Silva, Filipe Samuel; Sousa, Nuno; Carvalho, Óscar Samuel Novais; Catarino, Susana Oliveira

The simulation of light propagation in the head tissues has become of interest due to its applicability in transcranial photobiomodulation (tPBM). In silico studies appear as an effective way to research tPBM dosimetry and understand the light reach in the head tissues, as well as potential issues regarding tissue heating. Nonetheless, these computer models are still very simple and come with several limitation...


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