29 documents found, page 1 of 3
Loop diuretic discontinuation in chronic heart failure patients: A retrospectiv...
Silva, G; Moura, B; Moreira, E; Camila Dias, C; Sousa Pinto, B; Campelo, M; Amorim, S; Martins, E; Pinto, R; Maia Araújo, P; Resende, CX; Mena, BIntroduction and objectives: The use of loop diuretics is central in managing congestion in heart failure (HF), but their impact on prognosis remains unclear. In euvolemic patients, dose reduction is recommended, but there is no recommendation on their discontinuation. This study aims to assess the impact of loop diuretic discontinuation on the prognosis of outpatients with HF with reduced ejection fraction. Me...
Relatório científico da Expedição Oceano Azul - Cascais | Mafra | Sintra
Cabral, H; Afonso, CML; Almada, F; Almeida, S; Alonso, H; Andrade, J; Anjos, M; Batista, M; Bentes, L; Carvalho, AC; Celestino, S; Coelho, PD; Coxey, MA zona marítima dos concelhos de Cascais, Mafra e Sintra tem sido pouco estudada, não obstante situar-se frente a grandes centros urbanos e ser alvo de diversos usos e atividades humanas. Algumas das suas características geográficas e dos seus elementos notáveis ao nível dos fundos marinhos acrescem o seu interesse científico e patrimonial. Com o objectivo de ampliar o conhecimento científico sobre a biodiversi...
Hospital context in surgical site infection following colorectal surgery: a mul...
Malheiro, R; Peleteiro, B; Silva, G; Lebre, A; Paiva, JA; Correia, S"Background Surgical site infections (SSIs) are associated with poor health outcomes. Their incidence is highest after colorectal surgery, with little improvement in recent years. The role of hospital characteristics is undetermined. Aim To investigate whether SSI incidence after colorectal surgery varies between hospitals, and whether such variance may be explained by hospital characteristics. Methods Data wer...
Surveillance of surgical site infection after colorectal surgery: comprehensive...
Malheiro, RM; Peleteiro, B; Silva, G; Lebre, A; Paiva, JA; Correia, SObjective:The incidence of surgical site infection (SSI) is highest after colorectal surgery. We assessed the impact of risk factors for SSI using the population attributable fraction (PAF). Design:Retrospective cohort study. Setting:Portuguese hospitals performing regular surveillance. Patients:We identified patients who underwent colorectal procedures in hospitals that reported colorectal surgeries every year...
Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy agai...
Silva, G; Sales-Dias, J; Casal, D; Alves, S; Domenici, G; Barreto, C; Matos, C; Lemos, A; Matias, A; Kucheryava, K; Ferreira, A; Moita, MR; Braga, SThe Notch-signaling ligand DLL1 has emerged as an important player and promising therapeutic target in breast cancer (BC). DLL1-induced Notch activation promotes tumor cell proliferation, survival, migration, angiogenesis and BC stem cell maintenance. In BC, DLL1 overexpression is associated with poor prognosis, particularly in estrogen receptor-positive (ER+) subtypes. Directed therapy in early and advanced BC...
Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy agai...
Silva, G; Sales-Dias, J; Casal, D; Alves, S; Domenici, G; Barreto, C; Matos, C; Lemos, AR; Matias, AT; Kucheryava, K; Ferreira, A; Moita, MR; Braga, SAberrant Notch signaling is implicated in several cancers, including breast cancer. However, the mechanistic details of the specific receptors and function of ligand-mediated Notch signaling that promote breast cancer remains elusive. In our studies we show that DLL1, a Notch signaling ligand, is significantly overexpressed in ERα+ luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor pr...
Trends in respiratory management and morbidities of very preterm or very low bi...
Pinto-Lopes, R; Abreu-Pereira, S; Rocha, G; Flor-de-Lima, F; Rodrigues, C; Silva, G; Guedes, MB; Guimarães, HSummary: Considerable progress has been made regarding children’s morbidity and mortality. Nonetheless, recent developments have been insufficient to meet set targets. This study aims to evaluate trends and outcomes in respiratory management following a 14-year collaboration with the Vermont Oxford Network (VON). Methods: Data were collected prospectively at a Level III NICU in the North of Portugal and submitt...
Synchronous Gastric Tumours: Two Different Cases
Vicente, C; Santos, JA; Sacadura, J; Quaresma, L; Guedes da Silva, J; Caldeira Fradique, A; Silva, G; Oliveira, M; Costa, L; Esteves, J
Metabolic Profile and Cardiovascular Risk in a Population of Renal transplant r...
Gonçalves, M; Vieira, P; Resende, L; Durães, J; Rosa, N; Teixeira, JA; Silva, GIntroduction. Cardiovascular disease is more common in renal transplant recipients (RTRs) than in the general population, and is the major cause of both graft loss and patient death in RTRs. Objectives. This study aimed to characterize the cardiovascular risk factors, calculate the 7-year risk for major adverse cardiac events and the 7-year risk for death in a population of RTRs using a cardiovascular risk calc...
Adenocarcinoma do Íleon. Uma Entidade Rara e de Diagnóstico Tardio
Nabais, C; Salústio, R; Bispo, C; Sousa, F; Porto, E; Cardoso, C; Silva, G; Caldeira Fradique, AINTRODUÇÃO A neoplasia do intestino delgado é uma entidade rara, apresentando uma incidência anual de cerca de 2.1 casos por 100,000 pessoas, sendo o adenocarcinoma, o segundo tipo histológico mais frequente (em 33% dos casos). A localização distal deste tipo de tumor é menos habitual, o que torna o adenocarcinoma do íleon num evento invulgar. A raridade deste tipo de patologia, associada a uma apresentação clí...