11 documents found, page 1 of 2
PCR analysis of the effect of photodynamic therapy on breast tumors
Ferreira, Isabelle; Silva, Glenda Nicioli da; Ferreira-Strixino, Juliana; Grecco, Clovis; Bagnato, Vanderlei Salvador; Salvadori, Daisy Maria FaveroPhotodynamic therapy (PDT) is a promising therapeutic modality for treating cancer, including breast tumors. The oxidative damage caused by PDT culminates in cell death, induction of immune response, and the resulting destruction of the tumor. This study aimed to evaluate the gene expression profiling of genes BCL-2, BAX, and HER-2 and their proteins after PDT, associating it with the necrosis caused by this th...
Antitumoral activity of micellar solutions containing allyl isothiocyanate: an ...
Almeida, Tamires Cunha; Oliveira, Daiane Teixeira de; Ventura Savio, Andre Luiz [UNESP]; Perasoli, Fernanda Barcante; Silva, Glenda Nicioli daMade available in DSpace on 2021-06-25T11:48:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Introduction: Several natural products exhibit promising antineoplastic activity against bladder cancer cells, including allyl isothiocyanate (AITC). However, the AITC irritates the mucous membranes and induces eczematous or vesicular sk...
Polymeric micelles containing resveratrol: development, characterization, cytot...
Almeida, Tamires Cunha; Seibert, Janaina Brandão; Almeida, Sávio Henrique de Souza; Amparo, Tatiane Roquete; Teixeira, Luiz Fernando de MedeirosAntimicrobial and antitumor activities of resveratrol, a compound found mainly in grapes, have already been demonstrated. However, its low bioavailability is a limiting factor for therapeutic application. Polymeric micelles can be an approach to solve this problem since they can encapsulate hydrophobic substances. We developed and characterized micellar formulations containing resveratrol and evaluated their cy...
Increase of binucleated cells in the oral mucosa : a study on the use of psycho...
Oliveira, Luiza Barbosa de; Parreiras, Joyce Aparecida Rezende; Sebastião, Elza Conceição de Oliveira; Silva, Glenda Nicioli daThis study aimed to assess the prevalence of medical and nonmedical use of psychiatric medication among undergraduate students of health sciences from a public university in Brasil. Another objective was to determine the frequency of nuclear morphological abnormalities in the buccal mucosa of students using psychiatric drugs. A cross-sectional study based on a Web survey was carried out with 375 health sciences...
Anti-serum validation for use in immunohistochemistry for Trypanosoma cruzi det...
Azevedo, Paulo Hernane Rabelo; Xavier, Marcelo Antônio Pascoal; Silva, Glenda Nicioli da; Costa, Priscilla Almeida da; Carneiro, Cláudia MartinsIntroduction: The detection of Trypanosoma cruzi in tissue samples is important in many situations, such as testing of the reactivation of the infection. The detection of T. cruzi nests in endomyocardial biopsies (EMB) may be useful to evaluate graft rejection. Given their scarcity, such nests are not routinely identified. To increase the diagnosis sensitivity, immunohistochemistry (IHC) may serve as a promisin...
Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with d...
Oliveira, Daiane Teixeira de; Ventura Savio, Andre Luiz [UNESP]; Castro Marcondes, Joao Paulo de [UNESP]; Barros, Tatiane MartinsMade available in DSpace on 2018-11-26T17:20:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Universidade Federal de Ouro Preto (UFOP); Silibinin is a natural phenol found in the seeds of the milk ...
Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with d...
Oliveira, Daiane Teixeira de; Sávio, André Luiz Ventura; Marcondes, João Paulo de Castro; Barros, Tatiane Martins Barcelos; Barbosa, Ludmila CorreiaSilibinin is a natural phenol found in the seeds of the milk thistle plant. Recent data have shown its effectiveness for preventing/treating bladder tumours. Therefore, in this study we investigated the cytotoxic and toxicogenetic activity of silibinin in bladder cancer cells with different TP53 statuses. Two bladder urothelial carcinoma cell lines were used: RT4 (wild-type TP53 gene) and T24 (mutated TP53 gene...
Cell growth on 3D microstructured surfaces.
Araujo, Wagner Wlysses Rodrigues de; Teixeira, Fernanda de Sá; Silva, Glenda Nicioli da; Salvadori, Daisy Maria FáveroChinese Hamster Ovary (CHO) cell cultures were grown on surfaces lithographed with periodic 3D hexagonal microcavity array morphology. The range of microcavity size (inscribed circle diameter) was from 12 μm to 560 μm. CHO cells were grown also on flat surfaces. The characterization was performed with respect to cell growth density (number of nuclei per unit area) by fluorescence opticalmicroscopy and evaluated...
Cell cycle kinetics, apoptosis rates and gene expressions of MDR - 1, TP53, BCL...
Flórez, Luis Mauricio Montoya; Fêo, Haline Ballestero; Silva, Glenda Nicioli da; Yamatogi, Ricardo Seiti; Aguiar, Antonio José de AraujoTransmissible venereal tumour (TVT) generally presents different degrees of aggressiveness, which makes them unresponsive to conventional treatment protocols. This implies a progressive alteration of their biological profile. This study aimed to evaluate the cytotoxicity, cell survival, apoptosis and cell cycle alterations in TVT cell cultures subjected to treatment with vincristine. Similarly, it assessed poss...
Trypanosoma cruzi Discret Typing Units (TcII and TcVI) in samples of patients f...
Oliveira, Maykon Tavares de; Assis, Girley Francisco Machado de; Silva, Jaquelline Carla Valamiel de Oliveira e; Machado, Evandro Marques de MenezesBackground: Trypanosoma cruzi is classified into six discrete taxonomic units (DTUs). For this classification, different biological markers and classification criteria have been used. The objective was to identify the genetic profile of T. cruzi samples isolated from patients of two municipalities of Jequitinhonha Valley, MG, Brazil. Methods: Molecular characterization was performed using two different criteria...