4 documents found, page 1 of 1
Inhibition of CXCR2 Plays a Pivotal Role in Re-Sensitizing Ovarian Cancer to Ci...
Henriques, TB; Santos, DZ; Guimarães, IDS; Tessarollo, NG; Lyra-Junior, PCM; Mesquita, P; Pádua, D; Amaral, AL; Cavadas, B; Pereira, L; Silva, IVcDNA microarray data conducted by our group revealed overexpression of CXCL2 and CXCL8 in ovarian cancer (OC) microenvironment. Herein, we have proven that the chemokine receptor, CXCR2, is a pivotal molecule in re-sensitizing OC to cisplatin, and its inhibition decreases cell proliferation, viability, tumor size in cisplatinresistant cells, as well as reversed the overexpression of mesenchymal epithelium trans...
Sickle cell disease in children: chronic complications and search of predictive...
Silva, IV; Reis, AF; Palaré, MJ; Ferrão, A; Rodrigues, T; Morais, ABACKGROUND: Sickle cell disease (SCD) has extremely variable phenotypes, and several factors have been associated with the severity of the disease. OBJECTIVES: To analyze the chronic complications of SCD and look for predictive risk factors for increased severity and number of complications. METHODS: Retrospective study including all children followed for SCD in the Paediatric Haematology Unit of a tertiary hos...
Mastoidite aguda em idade pediátrica – Fatores de risco para complicações
Marques, F; Silva, IV; Branco, C; Paiva, M; Cunha, F
Epstein-Barr virus-associated cholestatic hepatitis
Salva, I; Silva, IV; Cunha, FEpstein-Barr virus infection is common in children, usually presenting as infectious mononucleosis, including fever, tonsillitis and lymphadenopathy associated with self-resolving increase in transaminases. Cholestasis is rare in children with only a few cases reported but it was described in up to 55% of the adult population affected. We present a case of a 6-year-old boy with fever, vomiting and choluria. The...