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Early-life exposure to non-nutritive sweeteners: Impact on adipose tissue morph...

Oliveira-Barbosa, Margarida; Bracchi, Isabella; Keating, Elisa; Negrão, Rita

Non-sugar sweeteners (NSS) are sugar alternatives widely incorporated into food and beverages (1), providing sweetness with negligible caloric contribution (2). Over the past two decades, their consumption has increased among pregnant women (3,4). In 2023, WHO discouraged NSS intake highlighting the need for studies regarding exposure during critical windows of development (5), such as pregnancy and childhood (...


Early-life exposure to non-nutritive sweeteners: effects on hepatic FGF21 pathw...

Brandão, Sofia; Bracchi, Isabella; Felipe, Stela Mirla; Magalhães, José; Keating, Elisa; Negrão, Rita

To combat obesity, diets and food products containing non-nutritive sweeteners (NNS), which provide sweetness without caloric intake, have gained popularity, even among pregnant women who reported intentional NNS consumption during gestation. In 2023, the World Health Organization warned about NNS consumption, as their long-term effects may be associated with an increased risk of type 2 diabetes, cardiovascular...


The cardiometabolic impact of rebaudioside a exposure during the reproductive s...

Bracchi, Isabella; Morais, Juliana; Coelho, João Almeida; Ferreira, Ana Filipa; Alves, Inês; Mendes, Cláudia; Correia, Beatriz; Gonçalves, Alexandre

Since foods rich in refined sugars promote obesity, the use of non-caloric sweeteners has gained popularity, and their consumption by pregnant women has increased. Stevia (a non-caloric sweetener) consumption was considered safe for humans by the European Food Safety Authority in a dose of up to 4 mg/kg body weight/day. However, the World Health Organization recommended in 2023 the restraint of these sweeteners...


Sociodemographic, lifestyle and anthropometric profile of vegetarian and omnivo...

Martins, Carina; Rocha, Inês; Pinheiro, Cátia; Giesteira, Liliana; Lucas, Ana; Alexandre, Ana Margarida; Ferreira, Catarina; Amaro, Joana


Sociodemographic, lifestyle and anthropometric profile of vegetarian and omnivo...

Martins, Catarina; Rocha, Inês; Pinheiro, Cátia; Giesteira, Liliana; Lucas, Ana; Alexandre, Ana; Ferreira, Catarina; Amaro, Joana; Amaral, Teresa


Vegetarian and omnivorous diets in Portugal: Sociodemographic and anthropometri...

Pinheiro, Cátia; Rocha, Inês; Giesteira, Liliana; Martins, Carina; Lucas, Ana; Alexandre, Ana Margarida; Ferreira, Catarina; Amaro, Joana


The relevance of polyphenols in obesity therapy

Faria, Ana; Pereira-Wilson, Cristina; Negrão, Rita

Polyphenols are secondary metabolites from plant metabolism, widely distributed in nature. The major dietary sources of polyphenols are fruits, vegetables, chocolate and plant-derived beverages like tea, coffee and wine. Polyphenols are mostly absorbed in the small intestine, extensively and quickly metabolized in the liver and appear in the circulation or are excreted into bile and urine as both intact and met...


Xanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin...

Negrão, Rita; Costa, Raquel; Duarte, Delfim; Gomes, Tiago Taveira; Coelho, Pedro; Guimarães, João T.; Guardão, Luísa; Azevedo, Isabel; Soares, Raquel

Angiogenesis and inflammation are two intermingled processes that play a role in wound healing. Nevertheless, whenever exacerbated, these processes result in nonhealing wounds. Xanthohumol (XN), a beer-derived polyphenol, inhibits these processes in many physiopathological situations. This study aimed at examining whether XN ingestion affects wound healing. Wistar rats drinking water, 5% ethanol, stout beer (SB...


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