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Porphyridium cruentum’s exopolysaccharides as versatile building blocks for new...

Duarte, Marta M.; Suprinovych, Artem; Ramos, Oscar L.; Costa, Joana R.; Lopes, Ana I.; Silva, Inês V.; Rojo, Luis; Ribeiro, Tânia B.; Pintado, Manuela

Introduction/resume: Marine algae and their metabolites have been widely recognized for their bioactive properties with applications in various industries, such as pharmaceutical, cosmetical, and nutraceutical. The red unicellular microalgae Porphyridium cruentum is a natural source for a variety of bioactive compounds, such as exopolysaccharides (EPS) and is already cultivated in large scale by several biotech...


Cutting-edge hybrid dressings: combining silk medical textiles and decellulariz...

Sousa, Teresa; Vale, Inês; Rosadas, Marta; Silva, Inês V.; Ribeiro, Viviana P.; Oliveira, Ana L.

Aim: Burns affect 11 million people globally each year, with 180,000 fatalities [1]. This study investigates a multilayer burn dressing combining silk fibroin (SF) fabric with highly- preserved decellularized porcine small intestine (dPSI) to support tissue regeneration and wound integration [2]. A silk sericin (SS) hydrogel is included as interface for structural integrity and anti-inflammatory benefits, enhan...


Biohybrid solutions for burn care: merging silk medical textiles with decellula...

Sousa, Teresa; Vale, Inês; Rosadas, Marta; Silva, Inês V.; Ribeiro, Viviana P.; Oliveira, Ana L.


Biohybrid dressings: integrating silk fibroin textiles with decellularized biol...

Sousa, Teresa; Vale, Inês; Rosadas, Marta; Silva, Inês V.; Ribeiro, Viviana P.; Oliveira, Ana L.

Burns affect 11 million people globally each year with 180,000 associated fatalities. This study proposes a multilayer hybrid dressing combining a silk fibroin (SF) textile with decellularized porcine small intestine (dPSI) capable of simultaneously provide wound protection and tissue regeneration. A silk sericin (SS) hydrogel was embedded into the decellularized tissue ensuring the integration with the textile...


Biohybrid solutions for burn care: merging silk medical textiles with decellula...

Sousa, Teresa; Vale, Inês; Rosadas, Marta; Silva, Inês V.; Ribeiro, Viviana P.; Oliveira, Ana L.


Microwave hydrodiffusion and gravity: a green extraction technology for phenyle...

Sousa, Ana Sofia; Sousa, Sérgio; Silva, Inês V.; Reis, Celso A.; Coscueta, Ezequiel R.; Pintado, Maria Manuela

Watercress is a cruciferous vegetable and the primary natural source of phenylethyl isothiocyanate (PEITC), a powerful health-promoting agent. Conventional extraction of PEITC relies on harmful solvents, which limits sustainability. This study introduces a novel, solvent-free method—microwave hydrodiffusion and gravity (MHG)—to extract PEITC from watercress by-products (WCBP). Results showed that freezing WCBP ...


Exploring rabbit skin as a novel decellularized dermal substitute for burn woun...

Rosadas, Marta; Sousa, Teresa; Silva, Inês V.; Sousa, Alda; Ribeiro, Viviana P.; Oliveira, Ana L.

Aim: Burn wounds represent a significant medical challenge. Autografts remain the standard treatment, however, are unsuitable for deep or extensive burns(1). Decellularized skin xenografts offer a viable alternative, having significantly reduced immunogenicity, still there is currently no skin-derived decellularized xenografic matrix due to its low resemblance to human skin (2)(3). This study proposes decellula...


Exploring rabbit skin as a novel decellularized dermal substitute for burn woun...

Rosadas, Marta; Sousa, Teresa; Silva, Inês V.; Sousa, Alda; Ribeiro, Viviana P.; Oliveira, Ana L.

Introduction: Burn wounds remain a significant challenge in medical care, requiring effective wound coverage to restore the skin barrier and promote healing or support skin reconstruction. The use of autologous grafts as substitutes is still the standard treatment, however, it presents limitations for deep and extensive burns (1). Decellularized skin allografts and xenografts have emerged as suitable options, u...


Insights on the hydrogel-forming ability of exopolysaccharide (EPS) from porphy...

Duarte, Marta M.; Suprinovych, Artem; Veiga, Anabela; Silva, Inês V.; Oliveira, Ana L.

Marine algae and their metabolites have been widely recognized for their bioactive properties with applications in various industries, such as nutraceutical, cosmetical, and pharmaceutical. In this work the extracted sulfated exopolysaccharides (EPS) from Porphyridium cruentum were analyzed for their hydrogel-forming ability and potential to be used as a new platform for healing and regeneration of chronic woun...


Valorization of rabbit skin for the development of decellularized matrices for ...

Rosadas, Marta; Sousa, Teresa; Silva, Inês V.; Sousa, Alda; Oliveira, Ana L.; Ribeiro, Viviana P.

Caught in the middle of the transition to a circular economy and emergent call for sustainable solutions, the agro-food industry is undoubtedly a sector that needs action. With a significant generation of by-products, the search for reuse methods to reduce its environmental impact while enhancing its economic value is necessary. The utilization of animal tissue by-products, namely skin, emerges as a promising o...


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