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Determination of potential childhood asthma biomarkers using a powerful methodo...

Berenguer, Pedro H.; Camacho, Irene C.; Câmara, Rita; Oliveira, Susana; Câmara, José S.

Leukotrienes and prostaglandins are arachidonic acid bioactive derived eicosanoids and key mediators of bronchial inflammation and response modulation in the airways contributing to the pathophysiology of asthma. An easy-to-use ultra-high pressure liquid chromatography (UHPLC)-based strategy was developed to characterize biomarkers of lipid peroxidation: leukotrienes E (LTE4) and B4 (LTB4) and 11β-prostaglandin...


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