103 documents found, page 1 of 11
Interplay between western diet and mammary cancer: data from a chemically-induc...
Silva, J; Azevedo, T; Aires, I; Peixoto, F; Neuparth, MJ; Faustino-Rocha, AI; Duarte, JA; Oliveira, PABackground/Aim: This study aimed to investigate the influence of Western diet on mammary cancer in Wistar female rats, focusing on systemic responses and tumor development. Materials and Methods: Twenty-eight Wistar female rats were acclimatized and divided into four experimental groups (n=7 each): Western diet (WD), Western diet with N-methyl-N- nitrosourea (MNU) administration (WD+MNU), standard diet (CTR), a...
Mammary cancer models: an overview from the past to the future
Silva, J; Oliveira, PA; Duarte, JA; Faustino-Rocha, AIAbstract. Breast cancer research heavily relies on diverse model systems to comprehend disease progression, develop novel diagnostics, and evaluate new therapeutic strategies. This review offers a comprehensive overview of mammary cancer models, covering both ex vivo and in vivo approaches. We delve into established techniques, such as cell culture and explore cutting-edge advancements, like tumor-on-a-chip and...
Effects of ladder-climbing exercise on mammary cancer: data from a chemically i...
Silva, J; Azevedo, T; Faustino-Rocha, AI; Oliveira, PA; Duarte, JABreast cancer is a major health concern for both humans and companion animals, particularly female dogs and cats. This study explores whether resistance training can influence the development of mammary cancer in female rats. The rats were divided into four groups, including those that exercised by climbing a ladder with increasing weight three times a week for 18 weeks. At the end of the study, tumor developme...
The impact of a Western diet and resistance training in a rat model of mammary ...
Silva, J; Azevedo, T; Faustino-Rocha AI; Duarte, JA; Oliveira, PAThis study aimed to investigate the impact of a Western diet and resistance training on cardiac remodeling in a rat model of chemically induced mammary cancer. Fifty-six female Wistar rats were randomly assigned to one of eight experimental groups, evaluating the impact of Western and standard diets, exercise and sedentarism, and the induction of mammary cancer. Mammary cancer was induced via the intraperitonea...
The role of natural compounds in rat mammary cancer: the beneficial effects of ...
Azevedo, Tiago; Silva, J; Faustino-Rocha, Ana I; Valada, A; Anjos, L; Moura, T; Ferreira, T; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, FBreast cancer is the most diagnosed cancer among women, and a leading cause of death worldwide. Santolina chamaecyparissus L. is a plant with multiple health benefits, includ- ing anticancer and anti-diabetic properties. This study aimed to assess the chemopreven- tive effects of S. chamaecyparissus aqueous ex- tract (SCE) in an animal model of mammary cancer. A total of 28 four-week-old female Wistar rats were...
Realistic aspects behind the application of the rat model of mammary cancer che...
Silva, J; Faustino-Rocha, Ana I; Duarte, JA; Oliveira, PACancer is one of the most important public health problems worldwide. Despite the great contribution of in-vitro studies for biomedical research, animals are essential to study diseases’ biopathology and diagnosis, and searching for new preventive and therapeutic strategies. Breast cancer is currently the most common cancer globally, accounting for 12.5% of all new annual cancer cases worldwide. Although the ra...
Studying and analyzing humane endpoints in the fructose-fed and streptozotocin-...
Silva-Reis, R; Faustino-Rocha, Ana I; Silva, J; Valada, A; Azevedo, T; Anjos, L; Gonçalves, L; Pinto, ML; Ferreira, R; Silva, AM; Cardoso, SMThis study assessed a humane endpoint scoring system to detect animal suffering in a rat model of type 2 diabetes. Sprague-Dawley male rats were divided into control and induced (fructose-fed and streptozotocin (STZ) administration) groups. Induced animals drank 10% fructose for 14 days, then received STZ (40 mg/kg) intraperitoneally. Weekly monitoring of body weight, water, and food consumption, 14 parameters ...
Mammary tumors incidence: a comparison between three studies carried out in fem...
Silva, J; Faustino-Rocha, Ana I; Oliveira, PA; Duarte, JAIntroduction: Breast cancer is still one of the most frequent malignancies among women. The mammary lesions induced by the carcinogen N-methyl-N-nitrosourea (MNU) are remarkably comparable to those observed in women. This work aimed to compare the mammary cancer incidence in female rats exposed to MNU in three different experimental protocols, envisioning to study mammary cancer development and progression. Mat...
Effect of exercise training on hematological and biochemical parameters: data f...
Silva, J; Azevedo, T; Anjos, L; Moura, T; Faustino-Rocha, Ana I; Oliveira, PA; Duarte, JABreast cancer is the most common oncological disease among women. The lifestyle, including physical activity and diet may prevent it. This study assessed the impact of exercise training on hematological and biochemical parameters in a rat model of mammary cancer. Twenty-eight female rats were randomly divided into four groups (n=7): Sedentary (SED); SED+N-methyl-N-nitrosourea (MNU); Exercised (EX); and EX+MNU. ...
Effects of resistance training in the development of mammary tumors MNU-induced...
Silva, J; Azevedo, T; Valada, A; Anjos, L; Faustino-Rocha, Ana I; Oliveira, PA; Duarte, JAEffects of resistance training in the development of mammary tumors MNU-induced in Wistar rats