14 documents found, page 1 of 2

Sulfur-containing compounds from fungi

Sulfur contributes greatly to the chemical richness of nature and, due to its unique properties, enables essential biological interactions that no other element can. Sulfur-containing compounds are bioactive/nutraceuticals substances from different sources, including fungi. They comprise sulfur atoms that are cyclically or noncyclically bonded to a cyanate group or a carbon atom. Sulfur-containing compounds, al...

A novel approach to assess balneotherapy effects on musculoskeletal diseases - ...

The present study aimed to evaluate whether a 14-day period of balneotherapy influences the inflammatory status, health-related quality of life (QoL) and quality of sleep, underlying overall health state, and clinically relevant benefits of patients with musculoskeletal diseases (MD). The health-related QoL was evaluated using the following instruments: 5Q-5D-5L, EQ-VAS, EUROHIS-QOL, B-IPQ, and HAQ-DI. The qual...

Antitumor effect of chalcone derivatives against human prostate (LNCaP and PC-3...

Chalcones are synthetic and naturally occurring compounds that have been widely investigated as anticancer agents. In this work, the effect of chalcones 1–18 against the metabolic viability of cervical (HeLa) and prostate (PC-3 and LNCaP) tumor cell lines was tested, to compare the activity against solid and liquid tumor cells. Their effect was also evaluated on the Jurkat cell line. Chalcone 16 showed the high...

Alkaloids from fungi

The prospection of unusual sources and undiscovered habitats is valuable in natural product research. Indeed, the fungi kingdom has received special attention since its ability to produce novel and intriguing secondary metabolites with various biological uses. Among secondary metabolites, alkaloid-derived structures present a wide range of bioactivities, including antineurodegenerative, antidepressive, anxiolyt...

Plasmatic microRNAs and treatment outcomes of patients with metastatic castrati...

Prostate cancer (PCa) is one of the most common malignancies among men worldwide. Inevitably, all advanced PCa patients develop metastatic castration-resistant prostate cancer (mCRPC), an aggressive phase of the disease. Treating mCRPC is challenging, and prognostic tools are needed for disease management. MicroRNA (miRNA) deregulation has been reported in PCa, constituting potential non-invasive prognostic bio...

Thermalism as A Determinant of Quality of Life and Sleep: A Novel Approach to T...

Thermalism has been used to improve health status, with emphasis on well-being, including relaxation, stress relief, depression, and even recovery and energy reserve. This study aimed to evaluate the perception of quality of life (QOL) by SF 36v2, and the quality of sleep, using the Pittsburgh Index, in individuals who attended the therapeutic thermalism at Chaves thermal Spa, in different treatment time points...

Avaliação da qualidade de vida e de sono dos termalistas do balneário termal de...

Atualmente, cada vez mais as pessoas recorrem ao termalismo para melhorar a saúde na sua ampla dimensão, com destaque para o bemestar, incluindo o relaxamento, alívio de stress, depressão, e mesmo recuperação e reservatório de energias. Os tratamentos termais proporcionam uma harmonia corporal integral e condições para prevenir possíveis patologias, inclusive de cariz mental e social, visando uma melhor qualida...

Antimicrobials from medicinal plants: an emergent strategy to control oral biof...

Oral microbial biofilms, directly related to oral diseases, particularly caries and periodontitis, exhibit virulence factors that include acidification of the oral microenvironment and the formation of biofilm enriched with exopolysaccharides, characteristics and common mechanisms that, ultimately, justify the increase in antibiotics resistance. In this line, the search for natural products, mainly obtained thr...

Effect of 1-carbaldehyde-3,4-dimethoxyxanthone on prostate and HPV-18 positive ...

Xanthone derivatives have shown promising antitumor properties, and 1-carbaldehyde-3,4- dimethoxyxanthone (1) has recently emerged as a potent tumor cell growth inhibitor. In this study, its effect was evaluated (MTT viability assay) against a new panel of cancer cells, namely cervical cancer (HeLa), androgen-sensitive (LNCaP) and androgen-independent (PC-3) prostate cancer, and nonsolid tumor derived cancer (J...

Prevalence of Neisseria gonorrhoeae and Trichomonas vaginalis in portuguese wom...