17 documents found, page 1 of 2
Acute total occlusion of the unprotected left main coronary artery: Patient cha...
Calvão, João; Braga, Marta; Brandão, Mariana; Campinas, Andreia; Alexandre, André; Amador, Ana; Costa, Catarina; Silva, João C.; Silva, MarisaIntroduction and objectives: Acute total occlusion of the unprotected left main coronary artery (LMCA) is a dramatic event. There are limited data regarding this population. We aimed to describe the clinical presentation and outcomes of patients and to determine predictors of in-hospital mortality. Methods: This retrospective study included patients presenting with acute (<12 h) myocardial infarction due to tot...
3D bioprinting of novel κ-carrageenan bioinks : an algae-derived polysaccharide
Marques, Diana M. C.; Silva, João C.; Serro, Ana Paula; Cabral, Joaquim M. S.; Sanjuan-Alberte, Paola; Ferreira, Frederico C.Novel green materials not sourced from animals and with low environmental impact are becoming increasingly appealing for biomedical and cellular agriculture applications. Marine biomaterials are a rich source of structurally diverse compounds with various biological activities. Kappa-carrageenan (κ-c) is a potential candidate for tissue engineering applications due to its gelation properties, mechanical strengt...
Corncob cellulose scaffolds: A new sustainable temporary implant for cartilage ...
Cordeiro, Rachel; Henriques, Marta; Silva, João C.; Antunes, Filipe; Alves, Nuno; Moura, CarlaTissue engineering using scaffolds is a promising strategy to repair damaged articular cartilage, whose self-repair is inefficient. Cellulose properties have been recognized for their application in the biomedical field. The aim of this study was to fabricate and characterize novel scaffolds based on poly(E-caprolactone) (PCL) and sustainable cellulose. Thus, the performance of corncob-derived cellulose (CC) in...
Additive manufactured Poly("-caprolactone)-graphene scaffolds: Lamellar crystal...
Biscaia, Sara; Silva, João C.; Moura, Carla; Viana, Tânia; Tojeira, Ana; Mitchell, Geoffrey R.; Pascoal-Faria, Paula; Ferreira, Frederico CasteloUnderstanding the mechano–biological coupling mechanisms of biomaterials for tissue engineering is of major importance to assure proper scaffold performance in situ. Therefore, it is of paramount importance to establish correlations between biomaterials, their processing conditions, and their mechanical behaviour, as well as their biological performance. With this work, it was possible to infer a correlation be...
Development of polycarbonate urethane-based materials with controlled diclofena...
Oliveira, Andreia S.; Ferreira, Inês; Branco, Ana C.; Silva, João C.; Costa, Carolina; Nolasco, Pedro; Marques, Ana C.; Silva, Diana; Colaço, Rogérioydrogels are very promising human cartilage replacement materials since they are able to mimic its structure and properties. Besides, they can be used as platforms for drug delivery to reduce inflammatory postsurgical reactions. Polycarbonate urethane (PCU) has been used in orthopedic applications due to its long-term biocompatibility and bio-durability. In this work, PCU-based hydrogels with the ability to rel...
PEDOT:PSS-coated polybenzimidazole electroconductive nanofibers for biomedical ...
Sordini, Laura; Silva, João C.; Garrudo, Fábio F. F.; Rodrigues, Carlos A. V.; Marques, Ana C.; Linhardt, Robert J.; Cabral, Joaquim S. M.Bioelectricity drives several processes in the human body. The development of new materials that can deliver electrical stimuli is gaining increasing attention in the field of tissue engineering. In this work, novel, highly electrically conductive nanofibers made of poly [2,20 - m-(phenylene)-5,50 -bibenzimidazole] (PBI) have been manufactured by electrospinning and then coated with cross-linked poly (3,4-ethyl...
A multimodal stimulation cell culture bioreactor for tissue engineering: A nume...
Meneses, João; Silva, João C.; Fernandes, Sofia R.; Datta, Abhishek; Ferreira, Frederico Castelo; Moura, Carla; Amado, Sandra; Alves, NunoThe use of digital twins in tissue engineering (TE) applications is of paramount importance to reduce the number of in vitro and in vivo tests. To pursue this aim, a novel multimodal bioreactor is developed, combining 3D design with numerical stimulation. This approach will facilitate the reproducibility between studies and the platforms optimisation (physical and digital) to enhance TE. The new bioreactor was ...
Effects of glycosaminoglycan supplementation in the chondrogenic differentiatio...
Silva, João C.; Moura, Carla; Matos, António P. Alves de; Cabral, Joaquim M. S.; Linhardt, Robert J.; Ferreira, Frederico CasteloThe lack of effective and long-term treatments for articular cartilage defects has increased the interest for innovative tissue engineering strategies. Such approaches, combining cells, biomaterial matrices and external biochemical/physical cues, hold promise for generating fully functional cartilage tissue. Herein, this study aims at exploring the use of the major cartilage glycosaminoglycans (GAGs), chondroit...
Extruded bioreactor perfusion culture supports the chondrogenic differentiation...
Silva, João C.; Moura, Carla; Borrecho, Gonçalo; Matos, António P. Alves de; Silva, Cláudia L. da; Cabral, Joaquim M. S.; Bártolo, Paulo J.Novel bioengineering strategies for the ex vivo fabrication of native-like tissue-engineered cartilage are crucial for the translation of these approaches to clinically manage highly prevalent and debilitating joint diseases. Bioreactors that provide different biophysical stimuli have been used in tissue engineering approaches aimed at enhancing the quality of the cartilage tissue generated. However, such syste...
Extracellular matrix decorated polycaprolactone scaffolds for improved mesenchy...
Silva, João C.; Carvalho, Marta S.; Udangawa, Ranodhi N.; Moura, Carla; Cabral, Joaquim M. S.; Silva, Cláudia L. da; Ferreira, Frederico CasteloThe clinical demand for tissue-engineered bone is growing due to the increase of non-union fractures and delayed healing in an aging population. Herein, we present a method combining additive manufacturing (AM) techniques with cell-derived extracellular matrix (ECM) to generate structurally well-defined bioactive scaffolds for bone tissue engineering (BTE). In this work, highly porous three-dimensional polycapr...