37 documents found, page 1 of 4
In vitro optimization of photobiomodulation and ultrasound stimulation protocol...
Monteiro, Francisca; Oliveira, Sofia; Marques, Carlos; Papadimitriou, Georgia; Silva, Joana M.; Padrão, Jorge; Sotiropoulos, Ioannis; Catarino, SusanaThe effectiveness of transcranial photobiomodulation (tPBM) and ultrasound stimulation (tUS) to mitigate different neuropathological mechanisms and stimulate neuroprotective responses has been vastly demonstrated in preclinical disease models. However, the translation into clinics is still suboptimal, revealing the need for more solid basic research to ascertain the most effective stimulation parameters to modu...
Glial-restricted precursors stimulate endogenous cytogenesis and effectively re...
Martins-Macedo, Joana; Araújo, Bruna; Anjo, Sandra I.; Silveira-Rosa, Tiago; Patrício, Patrícia; Alves, Nuno Dinis; Silva, Joana M.; Teixeira, Fábio G.Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on cognitive and emotional domains. Despite playing a critical role in brain homeostasis, the importance of gliogenesis has been overlooked, both in healthy and dise...
Comparing deep eutectic solvents and cyclodextrin complexes as curcumin vehicle...
Silva, Eduardo; Aroso, Ivo M.; Silva, Joana M.; Reis, R. L.Curcumin (Cur), a polyphenolic compound derived from Curcuma longa L., has garnered the attention of the scientifc community due to its remarkable biological properties such as its potential as a photosensitizing agent for photodynamic therapy (PDT). However, due to its low solubility in aqueous media and instability at physiological and alkaline pH, Cur has struggled to fnd relevant clinical application. To ta...
Preventing microbial infections with natural phenolic compounds
Ecevit, Kardelen; Barros, Alexandre A.; Silva, Joana M.; Reis, R. L.The struggle between humans and pathogens has taken and is continuing to take countless lives every year. As the misusage of conventional antibiotics increases, the complexity associated with the resistance mechanisms of pathogens has been evolving into gradually more clever mechanisms, diminishing the effectiveness of antibiotics. Hence, there is a growing interest in discovering novel and reliable therapeutic...
Surface functionalization of ureteral stents-based polyurethane: engineering an...
Ecevit, Kardelen; Silva, Eduardo Alexandre Pereira; Rodrigues, Luísa Cidália Guimarães; Aroso, Ivo; Barros, Alexandre A.; Silva, Joana M.; Reis, R. L.Bacterial colonization of polyurethane (PU) ureteral stents usually leads to severe and challenging clinical complications. As such, there is an increasing demand for an effective response to this unmet medical challenge. In this study, we offer a strategy based on the functionalization of PU stents with chitosan-fatty acid (CS-FA) derivatives to prevent bacterial colonization. Three different fatty acids (FAs)...
Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
Soares-Cunha, Carina; Vasconcelos, Nivaldo António Portela; Coimbra, Bárbara; Domingues, Ana Verónica; Silva, Joana M.; Loureiro-Campos, EduardoDeficits in decoding rewarding (and aversive) signals are present in several neuropsychiatric conditions such as depression and addiction, emphasising the importance of studying the underlying neural circuits in detail. One of the key regions of the reward circuit is the nucleus accumbens (NAc). The classical view on the field postulates that NAc dopamine receptor D1-expressing medium spiny neurons (D1-MSNs) co...
Optimal design of THEDES based on Perillyl Alcohol and Ibuprofen
Silva, Eduardo Alexandre Pereira; Oliveira, F.; Silva, Joana M.; Matias, A.; Reis, R. L.; Duarte, Ana Rita C.Therapeutic deep eutectic systems (THEDES) have dramatically expanded their popularity in the pharmaceutical field due to their ability to increase active pharmaceutical ingredients (APIs) bioavailability. However, their biological performance has not yet been carefully scrutinized. Herein, THEDES based on the binary mixture of perillyl alcohol (POH) and ibuprofen (IBU) were prepared using different molar ratio...
Assessment of environmental health based on a complementary approach using meta...
Laranjeiro, Maria I.; Alves, Luís M.; Silva, Joana M.; Calado, Joana G.; Norte, Ana C.; Paiva, Vítor H.; Lemos, Marco F.L.; Ramos, Jaime A.Metal pollution is currently a major issue in marine ecosystems, as organisms, and particularly seabirds, are exposed and accumulating increased levels from several anthropogenic sources. A set of 13 metals were quantified in two gull species breeding in sympatry, and in two distinct colonies separated by ca. 400 km. Oxidative stress was measured, and stable isotope analyses were used to link metal contaminatio...
Therapeutic role of deep eutectic solvents based on menthol and saturated fatty...
Silva, Joana M.; Pereira, Carolina Jesus Vieira; Mano, Francisca; Silva, Eduardo; Castro, Vânia Isabel Baptista; Sá-Nogueira, Isabel; Reis, R. L.The breakthroughs achieved in green solvents promote the emergence of therapeutic deep eutectic solvents (THEDES), which possess intriguing possible applications in the biomedical field. Herein, the main aim was to unravel the biomedical potential of hydrophobic THEDES based in menthol and saturated fatty acids with different chain lengths (e.g., stearic acid (SA), myristic acid (MA), and lauric acid (LA)). Our...
The energetic brain - A review from students to students
Bordone, Melina Paula; Salman, Mootaz M.; Titus, Haley E.; Amini, Elham; Andersen, Jens V.; Chakraborti, Barnali; Diuba, Artem V.The past 20 years have resulted in unprecedented progress in understanding brain energy metabolism and its role in health and disease. In this review, which was initiated at the 14th International Society for Neurochemistry Advanced School, we address the basic concepts of brain energy metabolism and approach the question of why the brain has high energy expenditure. Our review illustrates that the vertebrate b...