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Preconditioning with L-Ala-Gln reduces the expression of inflammatory markers (...

Oliveira, Leidelamar Rosário Alves de; Albuquerque, Andréa de Oliveira; Silva, Cícero Igor Simões Moura; Silva, Jussara Mathiele

Purpose: To evaluate the neuroprotective effect of L-alanyl-glutamine in a gerbil model of brain ischemia-reperfusion injury based on immunohistochemical quantification of pro-inflammatory and cell activation biomarkers (TNF-α, NF-κB, IL-6 and HO-1). Methods: Male gerbils weighing 100-180 g were pretreated with either 0.75 g/kg L-Ala-Gln (n=18) or 2.0 mL saline (n=18) administered i.v. 30 minutes before the bil...

Date: 2021   |   Origin: Oasisbr
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