2 documents found, page 1 of 1
Non-canonical Wnt signaling regulates junctional mechanocoupling during angioge...
Carvalho, Joana R.; Fortunato, Isabela C.; Fonseca, Catarina; Pezzarossa, Anna; Barbacena, Pedro; Dominguez-Cejudo, Maria AngelesMorphogenesis of hierarchical vascular networks depends on the integration of multiple biomechanical signals by endothelial cells, the cells lining the interior of blood vessels. Expansion of vascular networks arises through sprouting angiogenesis, a process involving extensive cell rearrangements and collective cell migration. Yet, the mechanisms controlling angiogenic collective behavior remain poorly underst...
YAP and TAZ regulate adherens junction dynamics and endothelial cell distributi...
Neto, Filipa; Klaus-Bergmann, Alexandra; Ong, Yu Ting; Alt, Silvanus; Vion, Anne-Clémence; Szymborska, Anna; Carvalho, Joana R.; Hollfinger, IreneFormation of blood vessel networks by sprouting angiogenesis is critical for tissue growth, homeostasis and regeneration. How endothelial cells arise in adequate numbers and arrange suitably to shape functional vascular networks is poorly understood. Here we show that YAP/TAZ promote stretch-induced proliferation and rearrangements of endothelial cells whilst preventing bleeding in developing vessels. Mechanist...