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Ecomorphological analysis of bovid remains from the Plio-Pleistocene hominin-be...

The site of Kromdraai is known for the first discovery of Paranthropus robustus remains. Research conducted at Kromdraai shows its rich fossiliferous deposits, geological complexity and potential to highlight the evolutionary history of Plio-Pleistocene hominin lineages in a dynamic and changing environment. Here, we provide the results of the first application of ecomorphology to bovid postcranial specimens fr...

Is creativity a reality in Bulgaria cities? An empirical study in the pre-pande...

This study aims to obtain a composite index characterizing Bulgarian districts about their creativity by presenting results for the pre-pandemic. The composite index developed by Rodrigues and Franco (2019), use of quantitative method and multivariate statistical techniques have been used to answer this objective. From the data gathered primarily from NSI- The National Statistical Institute of Bulgaria, the res...

New fossil Bovidae (Mammalia: Artiodactyla) from Kromdraai Unit P, South Africa...

Kromdraai is a Plio-Pleistocene site located in the Cradle of Humankind (Gauteng Province, South Africa). It has produced diverse and abundant faunal assemblages and key hominin specimens like the holotype of Paranthropus robustus and early Homo. We provide the first taxonomic study of the Bovidae Family from the hominin-bearing Unit P at Kromdraai and discuss its potential to unravel its paleoecological contex...

The association between potential risk factors and cerebral white matter lesion...

Gait characteristics and their discriminative ability in patients with fabry di...

Fabry disease (FD) is a rare disease commonly complicated with white matter lesions (WMLs). WMLs, which have extensively been associated with gait impairment, justify further investigation of its implication in FD. This study aims to identify a set of gait characteristics to discriminate FD patients with/without WMLs and healthy controls. Seventy-six subjects walked through a predefined circuit using gait senso...

The effect of levodopa medication on stride time variability in patients with P...

EXTEND THE THRESHOLD FOR LIMB SALVAGE, A MULTIDISCIPLINARY APPROACH

Clinical case: A 48 years old indigent man, with history of smoking and chronic alcohol consumption. He was taken to the Hospital one month after leg trauma. Physical  exmamination showed extensive ulcer (25x15cm) on the anteromedial aspect of the left leg, with important signs of infection, as well as significant bone exposure of the tibial shaft. No femoral or dislal pulses in the affected limb. The case...

Quantification of cell cycle kinetics by EdU (5-ethynyl-2′-deoxyuridine)-couple...

We propose a novel single-deoxynucleoside-based assay that is easy to perform and provides accurate values for the absolute length (in units of time) of each of the cell cycle stages (G1, S and G2/M). This flow-cytometric assay takes advantage of the excellent stoichiometric properties of azide-fluorochrome detection of DNA substituted with 5-ethynyl-2'-deoxyuridine (EdU). We show that by pulsing cells with EdU...

O peso da motivação religiosa nos conflitos atuais

Forças militares portuguesas têm sido empenhadas, nas duas últimas décadas, em áreas de conflito onde, mesmo para o comum dos observadores, a motivação religiosa constitui pano de fundo ou é fator a ter em conta: Balcãs (Bósnia e Kosovo), Afeganistão e Líbano são os exemplos mais evidentes. No entanto, a orientação secular dos ocidentais muitas vezes encobre a importante influência do fator religioso nos confli...

Dynamic transitions in RNA polymerase II density profiles during transcription ...

Eukaryotic protein-coding genes are transcribed by RNA polymerase II (RNAPII) through a cycle composed of three main phases: initiation, elongation, and termination. Recent studies using chromatin immunoprecipitation coupled to high-throughput sequencing suggest that the density of RNAPII molecules is higher at the 3′-end relative to the gene body. Here we show that this view is biased due to averaging density ...