28 documents found, page 1 of 3
Portuguese Recommendations for the Use of Biological and Targeted Synthetic Dis...
Fernandes, BM; Guimarães, F; Almeida, DE; Neto, A; Tavares-Costa, J; Roxo Ribeiro, A; Quintal, A; Pereira, JP; Silva, L; Nóvoa, TS; Faustino, A; Vaz, CObjective: To update the recommendations for the treatment of rheumatoid arthritis (RA) with biological and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs), endorsed by the Portuguese Society of Rheumatology (SPR). Methods: These treatment recommendations were formulated by Portuguese rheumatologists taking into account previous recommendations, new literature evidence and consen...
Horner's Syndrome as a Complication of Ultrasound-Guided Central Cannulation: A...
Silva, L; Junqueira, AF; Pato, R; Farraposo, S; Cruz, AR; Rocha, TCannulation of the internal jugular vein is often necessary for the management of critically ill patients. Despite being a very common procedure and performed more and more safely, several complications still occur. Horner's Syndrome (HS) is one of those complications described before the use of ultrasound as a method of guidance. HS is caused by functional interruption of sympathetic nerve supply to the eye, l...
Portuguese recommendations for the use of biological and targeted synthetic dis...
Fernandes, Bruno Miguel; Guimarães, F; Almeida, DE; Neto, A; Tavares-Costa, J; Ribeiro, AR; Quintal, Alberto; Pereira, JP; Silva, L; Nóvoa, TSObjective: To update the recommendations for the treatment of rheumatoid arthritis (RA) with biological and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs), endorsed by the Portuguese Society of Rheumatology (SPR). Methods: These treatment recommendations were formulated by Portuguese rheumatologists taking into account previous recommendations, new literature evidence and consen...
Small-scale agricultural grassland management can affect soil fungal community ...
Fox, A; Widmer, F; Barreiro, A; Jongen, M; Musyoki, M; Vieira, Â; Zimmermann, J; Cruz, Cristina; Dimitrova-Mårtensson, L-M; Rasche, F; Silva, LA European transect was established, ranging from Sweden to the Azores, to determine the relative influence of geographic factors and agricultural small-scale management on the grassland soil microbiome. Within each of five countries (factor ‘Country’), which maximized a range of geographic factors, two differing growth condition regions (factor ‘GCR’) were selected: a favorable region with conditions allowing ...
Molecular characterization of a novel splicing mutation underlying mucopolysacc...
Coutinho, MF; Encarnação, M; Matos, L; Silva, L; Ribeiro, D; Santos, JI; João Prata, M; Vilarinho, L; Alves, SHere, we present the molecular diagnosis of a patient with a general clinical suspicion of Mucopolysaccharidosis, highlighting the different tools used to perform its molecular characterization. In order to decrease the turnaround time for the final report and contribute to reduce the “diagnostic odyssey”, which frequently afflicts affected families, the proband’s sample was simultaneously screened for mutation...
Agricultura Familiar : perceções e atitudes face ao uso de pesticidas
Costa, T; Silva, L; Aguiar, A; Correia, H; Guiné, Raquel; Costa, CArepresentando um importante contributo para a produção de bens alimentares, preservação das espécies tradicionais e proteção da biodiversidade. Em Portugal, os agricultores familiares assumem grande relevância territorial, económica e social (93% das explorações registadas). De entre as práticas agrícolas utilizadas por estes agricultores com maior impacto, quer no ambiente, quer na saúde humana, encontra-se a ...
Development of a wall system made with thermally optimized masonry and super in...
Sousa, R; Hipólito Sousa; Silva, L; Flores Colen, I; Pedroso, MOne aim from this nationally funded construction industry research project entitled Efficient Plus Wall, was to develop a sustainable and energy-efficient non-structural wall system. The main objective, however, was to develop a lightweight masonry wall incorporating an external thermal render which optimised both thermal and mechanical resistances in external walls. The masonry is made with a vertical perforat...
Azimuthal asymmetries of charged hadrons produced in high-energy muon scatterin...
COMPASS collaboration (225 authors); Bordalo, P; Franco, C; Nunes, A S; Quaresma, M; Quintans, C; Ramos, S; Silva, L; Stolarski, MSingle hadron azimuthal asymmetries in the cross sections of positive and negative hadron production in muon semi-inclusive deep inelastic scattering off longitudinally polarised deuterons are determined using the 2006 COMPASS data and also all deuteron COMPASS data. For each hadron charge, the dependence of the azimuthal asymmetry on the hadron azimuthal angle $\phi$ is obtained by means of a five-parameter fi...
Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glyca...
Loureiro, L; Sousa, D; Ferreira, D; Chai, W; Lima, L; Pereira, C; Lopes, C; Correia, V; Silva, L; Li, C; Santos, L; Ferreira, JA; Barbas, A; Palma, AIncomplete O-glycosylation is a feature associated with malignancy resulting in the expression of truncated glycans such as the sialyl-Tn (STn) antigen. Despite all the progress in the development of potential anti-cancer antibodies, their application is frequently hindered by low specificities and cross-reactivity. In this study, a novel anti-STn monoclonal antibody named L2A5 was developed by hybridoma techno...
Development of energy efficient masonry system
Sousa, R; Hipólito Sousa; Silva, L; Flores Colen, I; Pedroso, MThis paper presents the main aspects regarding the development of a sustainable and energy-efficient external wall system. This development is ongoing under the scope of a national funded research project with the construction industry. One of the main objectives was to develop a lightweight masonry and an external render with improved thermal behavior and enough mechanical strength to be used in infill/non-str...