3 documents found, page 1 of 1
Transcriptional Control of the Production of Aspergillus fumigatus Conidia-Born...
Rocha, Marina Campos; Tadini Marilhano Fabri, Joao Henrique; Silva, Lilian Pereira; Figueiredo Angolini, Celio Fernando; Bertolini, Maria Celia [UNESP]Made available in DSpace on 2021-06-25T15:06:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Aspergillus fumigatus produces diverse secondary metabolites whose biological functions and regulation remain to be understood. Despite the importance of the conidia for t...
The Aspergillus fumigatus Mismatch Repair MSH2 Homolog Is Important for Virulen...
Dos Reis, Thaila Fernanda; Silva, Lilian Pereira; de Castro, Patrícia Alves; do Carmo, Rafaela Andrade; Marini, Marjorie MendesThe genetic stability of every living organism depends on accurate DNA replication and repair systems. Here, we investigated the Aspergillus fumigatusMSH2 mismatch repair (MMR) gene MshA and how it impacts virulence and the evolution of azole resistance. We examined mshA gene variation in 62 environmental and clinical A. fumigatus strains. We have observed 12 strains with variants (18.2%), and 8 strains among t...
The influence of genetic stability on Aspergillus fumigatus virulence and azole...
Reis, Thaila Fernanda dos; Silva, Lilian Pereira; Castro, Patrícia Alves; Lima, Pollyne Borborema Almeida de; Carmo, Rafaela Andrade doGenetic stability is extremely important for the survival of every living organism, and a very complex set of genes has evolved to cope with DNA repair upon DNA damage. Here, we investigated the Aspergillus fumigatus AtmA (Ataxia-telangiectasia mutated, ATM) and AtrA kinases, and how they impact virulence and the evolution of azole resistance. We demonstrated that A. fumigatus atmA and atrA null mutants are hap...