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Nanoformulations for the Delivery of Dietary Anthocyanins for the Prevention an...

Nunes, Ana R.; Costa, Elisabete C.; Alves, Gilberto; Silva, Luís R.

Diabetes mellitus (DM) is a metabolic disease characterized by abnormal blood glucose levels-hyperglycemia, caused by a lack of insulin secretion, impaired insulin action, or a combination of both. The incidence of DM is increasing, resulting in billions of dollars in annual healthcare costs worldwide. Current therapeutics aim to control hyperglycemia and reduce blood glucose levels to normal. However, most mod...


Exploring the Antioxidant, Antidiabetic, and Antimicrobial Capacity of Phenolic...

Gonçalves, Ana C.; Nunes, Ana R.; Meirinho, Sara; Ayuso-Calles, Miguel; Roca-Couso, Rocío; Rivas, Raúl; Falcão, Amílcar; Alves, Gilberto; Silva, Luís R.

(1) Background: Nowadays, special attention has been paid to red and purple fruits, including blueberries and sweet cherries, since they are highly attractive to consumers due to their organoleptic properties, standing out due to their vibrant red and purple colours and sweet flavour, and nutritional value. (2) Methods: The present study evaluated the phenolic profile of phenolic-enriched extracts from blueberr...


Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies

Saraiva, Sofia M.; Jacinto, Telma A.; Gonçalves, Ana C.; Gaspar, Dário; Silva, Luís R.

Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant, antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several over-the-counter medications. This naturally derived bioactive compound is the best-known ingredient in coffee and other beverages, such as tea, soft drinks, and energy drinks, and is widely consumed worldwide. Therefore, it is ex...


Blackberries and Mulberries: Berries with Significant Health-Promoting Properties

Martins, Mariana S.; Gonçalves, Ana C.; Alves, Gilberto; Silva, Luís R.

Blackberries and mulberries are small and perishable fruits that provide significant health benefits when consumed. In reality, both are rich in phytochemicals, such as phenolics and volatile compounds, and micronutrients, such as vitamins. All the compounds are well-known thanks to their medicinal and pharmacological properties, namely antioxidant, anti-inflammatory, anti-cancer, antiviral, and cardiovascular ...


Modification of chicha gum antibacterial activity, ex vivo mucoadhesion, antiox...

Freitas, Alessandra R.; Ribeiro, António J.; Ribeiro, Alessandra B.; Collado-Gonzalez, Maria Del Mar; Silva, Luís R.; Alves, Luís; Melro, Elodie

The aim of the present work was to modify the exuded gum of Sterculia striata tree by an amination reaction. The viscosity and zero potential of the chicha gum varied as a function of pH. The modification was confirmed by X-ray diffraction (XRD), infrared spectroscopy (FTIR), size exclusion chromatography (SEC), zeta potential, thermogravimetric analysis (TG), and differential scanning calorimetry (DSC). Furthe...


Mineral Content and Volatile Profiling of Prunus avium L. (Sweet Cherry) By-Pro...

Nunes, Ana R.; Gonçalves, Ana C.; Pinto, Edgar; Amaro, Filipa; Flores-Félix, José D.; Almeida, Agostinho; Pinho, Paula Guedes de; Falcão, Amílcar

Large amounts of Prunus avium L. by-products result from sweet cherry production and processing. This work aimed to evaluate the mineral content and volatile profiling of the cherry stems, leaves, and flowers of the Saco cultivar collected from the Fundão region (Portugal). A total of 18 minerals were determined by ICP-MS, namely 8 essential and 10 non-essential elements. Phosphorus (P) was the most abundant mi...


Effects of Functional Phenolics Dietary Supplementation on Athletes' Performanc...

Gonçalves, Ana C.; Gaspar, Dário; Flores-Félix, José David; Falcão, Amílcar; Alves, Gilberto; Silva, Luís R.

In recent years, many efforts have been made to identify micronutrients or nutritional strategies capable of preventing, or at least, attenuating, exercise-induced muscle damage and oxidative stress, and improving athlete performance. The reason is that most exercises induce various changes in mitochondria and cellular cytosol that lead to the generation of reactive species and free radicals whose accumulation ...


Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Ric...

Gonçalves, Ana C.; Costa, Ana R.; Flores-Félix, José D.; Falcão, Amílcar; Alves, Gilberto; Silva, Luís R.

Cherries have largely been investigated due to their high content in phenolics in order to fully explore their health-promoting properties. Therefore, this work aimed to assess, for the first time, the anti-inflammatory potential of phenolic-targeted fractions of the Saco cherry, using RAW 264.7 macrophages stimulated with lipopolysaccharide. Additionally, the cytotoxic effects on gastric adenocarcinoma (AGS), ...


Evaluation of Raw Cheese as a Novel Source of Biofertilizer with a High Level o...

Nunes, Ana R.; Sánchez-Juanes, Fernando; Gonçalves, Ana C.; Alves, Gilberto Lourenço; Silva, Luís R.; Flores-Félix, José David

Today’s agriculture requires the search for new and modern tools in order to improve and expand the use of its crops and to increase their sustainability. The use of plant growth-promoting PGP bacteria (PGPB) is the target of much research and seems to be an ideal strategy as long as the strains are properly selected for this purpose. Among the bacteria, lactic acid bacteria (LAB) are considered a suitable alte...


Mineral content and volatile profiling of Prunus avium L. (sweet cherry) y-Prod...

Nunes, Ana R.; Gonçalves, Ana C.; Pinto, Edgar; Amaro, Filipa; Flores-Félix, José D.; Almeida, Agostinho; Pinho, Paula Guedes de; Falcão, Amílcar

Large amounts of Prunus avium L. by-products result from sweet cherry production and processing. This work aimed to evaluate the mineral content and volatile profiling of the cherry stems, leaves, and flowers of the Saco cultivar collected from the Fundão region (Portugal). A total of 18 min erals were determined by ICP-MS, namely 8 essential and 10 non-essential elements. Phosphorus (P) was the most abundant m...


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