2 documents found, page 1 of 1
Comprehensive molecular landscape of cetuximab resistance in head and neck canc...
Gomes, Izabela N. F.; Silva-Oliveira, Renato J. da; Silva, Luciane Sussuchi da; Martinho, Olga; Evangelista, Adriane F.; Helvoort Lengert, André vanCetuximab is the sole anti-EGFR monoclonal antibody that is FDA approved to treat head and neck squamous cell carcinoma (HNSCC). However, no predictive biomarkers of cetuximab response are known for HNSCC. Herein, we address the molecular mechanisms underlying cetuximab resistance in an in vitro model. We established a cetuximab resistant model (FaDu), using increased cetuximab concentrations for more than eigh...
Loss of 5 '-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade ...
Menezes, Weder Pereira de; Oliveira Silva, Viviane Aline; Faria Gomes, Izabela Natalia; Rosa, Marcela Nunes; Corcoll Spina, Maria LuisaMade available in DSpace on 2020-12-10T19:54:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Barretos Cancer Hospital; Public Ministry of Labor Campinas (Research, Prevention and Education of Occ...