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Unique crystal structure of a novel surfactant protein from the foam nest of th...
Hissa, Denise Cavalcante; Bezerra, Gustavo Arruda; Birner-Gruenberger, Ruth; Silva, Luciano Paulino; Usón, Isabel; Gruber, KarlBreeding by releasing eggs into stable biofoams ("foam nests") is a peculiar reproduction mode within anurans, fish, and tunicates; not much is known regarding the biochemistry or molecular mechanisms involved. Lv-ranaspumin (Lv-RSN-1) is the predominant protein from the foam nest of the frog Leptodactylus vastus. This protein shows natural surfactant activity, which is assumed to be crucial for stabilizing foa...
Fraternine, a novel wasp peptide, protects against motor impairments in 6-OHDA ...
Biolch, Andréia Mayer; Oliveira, Danilo Gustavo Rodrigues de; Amaral, Henrique de Oliveira; Campos, Gabriel Avohay Alves; Gonçalves, Jacqueline CoimbraParkinson’s disease (PD) is a progressive neurodegenerative condition that affects the Central Nervous System (CNS). Insect venoms show high molecular variability and selectivity in the CNS of mammals and present potential for the development of new drugs for the treatment of PD. In this study, we isolated and identified a component of the venom of the social wasp Parachartergus fraternus and evaluated its neur...
Bowman-Birk protease inhibitor from Vigna unguiculata seeds enhances the action...
Álvares, Alice da Cunha Morales; Schwartz, Elisabeth Nogueira Ferroni; Amaral, Nathalia Oda; Trindade, Neidiane Rosa; Pedrino, Gustavo RodriguesThe hydrolysis of bradykinin (Bk) by different classes of proteases in plasma and tissues leads to a decrease in its half-life. Here, Bk actions on smooth muscle and in vivo cardiovascular assays in association with a protease inhibitor, Black eyed-pea trypsin and chymotrypsin inhibitor (BTCI) and also under the effect of trypsin and chymotrypsin were evaluated. Two synthetic Bk-related peptides, Bk1 and Bk2, w...
Evaluation of cytotoxic and antimicrobial effects of two Bt cry proteins on a G...
Farias, Davi Felipe; Viana, Martônio Ponte; Oliveira, Gustavo Ramos de; Beneventi, Magda Aparecida; Soares, BrunoMarques; Pessoa, ClaudiaStudies have contested the innocuousness of Bacillus thuringiensis (Bt) Cry proteins to mammalian cells as well as to mammals microbiota.Thus, this study aimed to evaluate the cytotoxic and antimicrobial effects of two Cry proteins, Cry8Ka5 (a novelmutant protein) and Cry1Ac (a widely distributed protein in GM crops). Evaluation of cyto- and genotoxicity in human lymphocytes was performed as well as hemolytic a...