4 documents found, page 1 of 1
Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesi...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I.; Silva, Jéssica; Silva, Mónica G.; Pires, Maria João; Neuparth, Maria João; Vala, HelenaAim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, ...
Impact of Sea Warming and 17-α-Ethinylestradiol Exposure on the Lipid Metabolis...
Rodrigues, João A.; Bispo, Daniela S. C.; Silva, Mónica G.; Araújo, Rita; Soares, Amadeu M. V. M.; Freitas, Rosa; Gil, Ana M.This paper reports on an NMR metabolomics study of lipophilic extracts of Ruditapes philippinarum clams exposed to the hormonal contaminant 17-α-ethinylestradiol (EE2), at 17 °C and 21 °C. The results reveal that exposure at 17 °C triggers a weak response at low EE2 concentrations, suggestive of a slight increase in membrane rigidity, followed by lipid metabolic stability at higher EE2 concentrations. On the ot...
Concentrations levels and effects of 17alpha-Ethinylestradiol in freshwater and...
Almeida, Ângela; Silva, Mónica G.; Soares, Amadeu M. V. M.; Freitas, RosaPharmaceutical drugs are contaminants of emerging concern and are amongst the most frequent in the aquatic environment. Even though a vast literature indicate that pharmaceuticals exert negative impacts towards aquatic organisms, mainly in vertebrates, there is still limited information regarding the effects of these drugs in freshwater and marine bivalves. Marine bivalves have a high ecological and socio-econo...
The cyclooxigenase-2 Inhibitor parecoxib prevents epidermal dysplasia in HPV16-...
Ferreira, Tiago; Campos, Sandra; Silva, Mónica G.; Ribeiro, Rita; Santos, Susana; Almeida, José; Pires, Maria João; Costa, Rui Miguel G. daCarcinogenesis induced by high-risk human papillomavirus (HPV) involves inflammatory phenomena, partially mediated by cyclooxigenase-2. In pre-clinical models of HPV-induced cancer, cyclooxygenase-2 inhibitors have shown significant efficacy, but also considerable toxicity. This study addresses the chemopreventive effect and hepatic toxicity of a specific cyclooxigensase-2 inhibitor, parecoxib, in HPV16-transge...