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Prognosis value of p53, C-erB-2 and Ki67 proteins in ovarian carcinoma.

Frutuoso, C; Silva, M R; Amaral, N; Martins, I; De Oliveira, C; De Oliveira, H M

The prognosis in ovarian carcinoma remains poor. We need to identify patients who are less likely to respond to treatment. In order to evaluate the prognostic value of C-erb-B2, p53 and Ki 67 expression and correlate these markers with classic prognostic factors, we studied paraffin-embedded tumor tissue from 81 patients with epithelial ovarian cancer and made a quantitative evaluation of C-erb-B2, p53 and Ki 6...

Date: 2001   |   Origin: Acta Médica Portuguesa

The use of peripheral blood progenitor cells as an autologous hematopoietic sup...

Silva, M R; Passos-Coelho, J L; da Costa, F L; Machado, M A; Miranda, N; Miranda, M H; Parreira, A

We report the results of PBPC collection by large-volume leukaphereses and the hematologic recovery after high-dose chemotherapy supported by autologous PBPC reinfusion in a series of cancer patients treated at the Hematological Intensive Care Unit (UCHI) (Portuguese Institute of Oncology, Lisbon). Large volume leukaphereses were used to increase the efficacy of the PBPC collection. This modification of the sta...

Date: 1999   |   Origin: Acta Médica Portuguesa

The use of peripheral blood progenitor cells as an autologous hematopoietic sup...

Silva, M R; Passos-Coelho, J L; da Costa, F L; Machado, M A; Miranda, N; Miranda, M H; Parreira, A

We review the rationale for PBPC transplantation and the results reported in the literature. In order to prolong complete remissions and increase cure rates, high-dose chemotherapy is frequently used in the treatment of selected neoplasias. Hematological toxicity can be overcome by the infusion of autologous hemopoietic progenitors. Recently, peripheral blood is being used as the preferred source for hemopoieti...

Date: 1999   |   Origin: Acta Médica Portuguesa

Endobronchial biopsy and cytology. Comparative study.

Matos, R; Silva, M R; Carvalho, L

A retrospective study was performed in order to evaluate the diagnostic accuracy for lung cancer in histological biopsy specimens and in cytological examination taken at fibre optic bronchoscopy. Of 530 patients suspected of having a malignant lesion, 150 had pathological confirmation (group A) and 380 did not (group B). In group A biopsy was diagnosed in 78.7% and cytology in 58% of the cases, of which brushin...

Date: 1995   |   Origin: Acta Médica Portuguesa

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