9 documents found, page 1 of 1
T-cell branched glycosylation as a mediator of colitis-associated colorectal ca...
Leite-Gomes, E; Silva, MC; Dias, AM; Fernandes, Â; Faria, G; Nogueira, R; Santos-Pereira, B; Fernandes-Mendes, H; Azevedo, CM; Raposo, J; Portero, JLBackground and Aims: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, established as a risk factor for colorectal cancer (CRC) development. Long-standing inflammation appears to play a central role in colitis-associated colorectal cancer (CAC). However, the molecular mechanism underlying CAC progression is still elusive. Previous evidence showed that levels of b...
Repercussions of the COVID-19 Pandemic in the Emergency Department of Gynecolog...
Jovina Domingues, S; Ormonde, M; Miguel, A; Martins, A; Saavedra, I; Silva, MCObjective. COVID-19 has spread worldwide and Portugal decreed the State of Emergency on March 18th, 2020. During this period, the population was encouraged to stay at home. Still, there were no restrictions on access to health care. Therefore, we aimed to compare the major causes for attending the Obstetrics and Gynaecology Emergency Department (ED) from a referral centre (Maternidade Dr. Alfredo da Costa, in L...
Comprehensive perspective for lung cancer characterisation based on AI solution...
Pereira, T; Freitas, C; Costa, JL; Morgado, J; Silva, F; Negrão, E; Lima, BF; Silva, MC; Madureira, AJ; Ramos, I; Hespanhol, V; Cunha, A; Oliveira, HPLung cancer is still the leading cause of cancer death in the world. For this reason, novel approaches for early and more accurate diagnosis are needed. Computer-aided decision (CAD) can be an interesting option for a noninvasive tumour characterisation based on thoracic computed tomography (CT) image analysis. Until now, radiomics have been focused on tumour features analysis, and have not considered the infor...
Sharing biomedical data: Strengthening ai development in healthcare
Pereira, T; Morgado, J; Silva, F; Pelter, MM; Dias, VR; Barros, R; Freitas, C; Negrão, E; Lima, BF; Silva, MC; Madureira, AJ; Ramos, I; Hespanhol, VArtificial intelligence (AI)-based solutions have revolutionized our world, using extensive datasets and computational resources to create automatic tools for complex tasks that, until now, have been performed by humans. Massive data is a fundamental aspect of the most powerful AI-based algorithms. However, for AI-based healthcare solutions, there are several socioeconomic, technical/infrastructural, and most i...
Machine learning and feature selection methods for egfr mutation status predict...
Morgado, J; Pereira, T; Silva, F; Freitas, C; Negrão, E; Lima, BF; Silva, MC; Madureira, AJ; Ramos, I; Hespanhol, V; Costa, JL; Cunha, A; Oliveira, HPThe evolution of personalized medicine has changed the therapeutic strategy from classical chemotherapy and radiotherapy to a genetic modification targeted therapy, and although biopsy is the traditional method to genetically characterize lung cancer tumor, it is an invasive and painful procedure for the patient. Nodule image features extracted from computed tomography (CT) scans have been used to create machin...
Septic Shock Following Hysteroscopy. A Case Report
Meneses, T; Faria, J; Martins, AT; Delgado, E; Silva, MCIntroduction: Minimally invasive gynecological surgery such as hysteroscopy has a small risk of complications. These include uterine perforation (with or without adjacent pelvic organ lesion), bleeding and infection, and are more common in the presence of risk factors such as smoking, history of pelvic inflammatory disease (PID) and endometriosis. Case presentation: A patient submitted to a diagnostic hysterosc...
Glycans as key checkpoints of T cell activity and function
Pereira, MS; Alves, I; Vicente, M; Campar, A; Silva, MC; Padrão, NA; Pinto, V; Fernandes, Â; Dias, AM; Pinho, SSThe immune system is highly controlled and fine-tuned by glycosylation, through the addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell receptors. Despite a relative backlog in understanding the importance of glycans in the immune system, due to its inherent complexity, remarkable findings have been highlighting the essential contributions of glycosylation in the regulatio...
Laparoscopic Assisted Vaginal Hysterectomy Versus Vaginal Hysterectomy
Condeço, R; Barreto, S; Leitão, C; Silva, MC; Mira, RIntroduction: Hysterectomy is the commonest gynecologic operation, performed for malignant and benign conditions. There are many approaches to hysterectomy for benign disease. Studies comparing the techniques have showed that vaginal hysterectomy has benefits in terms of reduced hospital stay, faster recovery and less operating time. Objective: The purpose of this study is to compare the surgical and immediate ...
Office Hysteroscopy After Ultrasonographic Diagnosis of Thickened Endometrium i...
Cordeiro, A; Condeço, R; Leitão, C; Sousa, F; Coutinho, S; Silva, MC; Bernardo, MJ; Mira, RThe aim of our study was to access office hysteroscopy results in postmenopausal patients with thickened endometrium. A retrospective descriptive study was carried out on 245 postmenopausal patients submitted to office hysteroscopy after sonographic diagnosis of thickened endometriumin 20 consecutive months.Women were evaluated for age, hormonal therapy, hysteroscopic findings, procedure duration, complications...