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Oral glucose tolerance testing at 1 h and 2 h: relationship with glucose and ca...

Guerreiro, V; Maia, I; Neves, JS; Salazar, D; Ferreira, MJ; Mendonça, F; Silva, MM; Borges-Canha, M; Viana, S; Costa, C; Pedro, J; Varela, A; Lau, E

Background: One hour plasma glucose concentration (1hPG) during an oral glucose tolerance test (OGTT) may be an alternative to 2-h plasma glucose concentration (2hPG) in the identification of individuals at increased risk of hyperglycaemia, although its role is not fully understood. Aim: We aim to investigate the relationship of these measures with other glucose parameters, as well as their relationship with ca...


The impact of vitamin d in non-alcoholic fatty liver disease: A cross-sectional...

Borges-Canha, M; Neves, JS; Mendonça, F; Silva, MM; Costa, C; Cabral, PM; Guerreiro, V; Lourenço, R; Meira, P; Salazar, D; Ferreira, MJ; Pedro, J

Purpose: We aimed to evaluate the association between vitamin D status and hepatic function parameters and scores: Fatty Liver Index (FLI, predictor of hepatic steatosis) and BARD (BMI, AST/ALT ratio and DM, predictor of hepatic fibrosis) in patients with morbid obesity. Patients and Methods: Cross-sectional study including patients with morbid obesity followed in our centre between January 2010 and July 2018. ...


Beta Cell Function as a Baseline Predictor of Weight Loss After Bariatric Surgery

Borges-Canha, M; Neves, JS; Mendonça, F; Silva, MM; Costa, C; M Cabral, P; Guerreiro, V; Lourenço, R; Meira, P; Salazar, D; Ferreira, MJ; Pedro, J

Background: Obesity is a multifactorial disease, which is strongly associated to other metabolic disorders. Bariatric surgery is the most effective treatment of morbid obesity. The role of beta cell function in weight loss after bariatric surgery is uncertain. Aim: To evaluate the association between beta cell function and percentage of total body weight loss (TBWL%) 1, 2, 3, and 4 years after bariatric surgery...


Gut microbiota changes after metabolic surgery in adult diabetic patients with ...

Eva Lau Gouveia; Belda, E; Picq, P; Carvalho, Davide; Ferreira Magalhães, M; Silva, MM; Barroso, I; Correia, Flora; pina-vaz, c; Miranda, I

Background: Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of obesity, also improving metabolic and inflammatory status, in patients with mild obesity. The underlying mechanisms have not been fully understood, but gut microbiota is hypothesized to play a key role. Our aim was to evaluate the association between gut microbiota changes and anthropometric, metabol...


Adequate magnesium level as an associated factor of pre-diabetes and diabetes m...

Guerreiro, V; Maia, I; Neves, JS; Salazar, D; Ferreira, MJ; Mendonça, F; Silva, MM; Viana, S; Costa, C; Pedro, J; Varela, A; Lau, E; Freitas, P

Bariatric surgery (BS) can lead to remission of type 2 diabetes mellitus (T2DM), however, the evidence on the influence of preoperative serum magnesium levels on this reversal is scarce. To study the influence of preoperative serum magnesium levels on the pre-T2DM and T2DM remission one year after BS. Retrospective study carried out among 1656 patients with obesity who underwent BS in the Centro Hospitalar Univ...


Secondary Hyperparathyroidism Among Bariatric Patients: Unraveling the Prevalen...

Mendonça, FM; Neves, JS; Silva, MM; Borges Canha, M; Costa, C; Cabral, PM; Guerreiro, V; Lourenço, R; Meira, P; Correia, Flora; Salazar, D; Pedro, J

Introduction Bariatric surgery (BS) is the most effective therapeutic approach to obesity. It is associated with great gastrointestinal anatomic changes, predisposing the patients to altered nutrient absorption that impacts phosphocalcium metabolism. This study aimed to clarify the prevalence of secondary hyperparathyroidism (SHPT) and its predictors in patients submitted to BS. Methods Retrospective study of 1...


Bariatric Surgery Impact on Cardiovascular Risk Factors: Is Age a Factor to Con...

Mendonça, F; Silva, MM; Salazar, D; Correia, Flora; Pedro, J; Guerreiro, V; Viana, S; Neves, JS; Belo, S; Varela, A; Freitas, P; Carvalho, Davide

Introduction: Despite the abundance of data addressing the influence of patient's age on surgery-related complications, its impact on cardiometabolic outcomes following bariatric surgery has been overlooked. Methods: Retrospective unicentric study of 1,728 obese patients who underwent bariatric surgery between January 2010 and June 2015. Patients were divided in 3 age groups, according to their age at surgery: ...


Thyroid Function and the Risk of Non-Alcoholic Fatty Liver Disease in Morbid Ob...

Borges-Canha, M; Neves, JS; Mendonça, F; Silva, MM; Costa, C; Cabral, PM; Guerreiro, V; Lourenço, R; Meira, P; Salazar, D; Ferreira, MJ; Pedro, J

Background: An association between hypothyroidism and the risk of Non-alcoholic Fatty Liver Disease (NAFLD) has been suggested. This association remains to be elucidated in patients with morbid obesity. Aim: To evaluate the association between thyroid function and parameters of liver function and hepatic scores in patients with morbid obesity. Methods: Patients with morbid obesity followed in our center between...


Impact of Depression on Weight Variation after Bariatric Surgery: A Three-Year ...

Pedro, J; Neves, JS; Ferreira, MJ; Guerreiro, V; Salazar, D; Viana, S; Mendonça, F; Silva, MM; Brandão, I; Belo, S; Freitas, P; Varela, A; Carvalho, D

Introduction: The association between obesity and depression has been repeatedly established. However, little is known about the impact that the diagnosis of depression before bariatric surgery (DDBS) may have on weight loss. Objective: To evaluate the impact of DDBS on weight outcomes. Methods: Retrospective study of patients submitted to BS. Patients with no weight, no current medication data, or those submit...


Which Factors Are Associated with a Higher Prevalence of Anemia Following Baria...

Silva Ferreira, MJS; Salazar, DA; Neves, JS; Pires Pedro, JMP; Guerreiro, VA; Viana, SES; Mendonca, F; Silva, MM; Belo, SP; Sande, AV; Correia, Flora

Introduction Anemia in obese patients is common and multifactorial and is also a complication of bariatric surgery. The aim of this study is to establish which variables are associated with a higher prevalence of post-bariatric surgery anemia. Methods Retrospective cohort study involving 1999 patients submitted to bariatric surgery with a follow-up period of 4 years. Anthropometric, laboratorial parameters and ...


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