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Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens...

Silva, Ana; Pereira, Marta; Carrascal, Mylène A.; Brites, Gonçalo; Neves, Bruno; Moreira, Patrícia; Resende, Rosa; Silva, Maria Manuel

Experimental evidence highlights nuclear factor (erythroid-derived 2)-like 2 (Nrf2) as a molecular target in Alzheimer's disease (AD). The well-known effect of electrophilic cysteine-reactive skin allergens on Nrf2-activation led to the hypothesis that these compounds could have a therapeutic role in AD. This was further supported by the neuroprotective activity of the skin allergen dimethyl fumarate (DMF), dem...


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