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Scientific and technological investigation of the protective effect of rutin on...
Fideles, Lázaro de Sousa; Miranda, João Antônio Leal de; Pimentel, Paulo Vitor de Souza; Ribeiro, Maria Elenir Nobre PinhoChemotherapy is one of the main oncological treatments, in which it has several side effects, including mucositis. Rutin belongs to the class of flavonoids and has clinically relevant functions, potentially beneficial in preventing diseases and antioxidant activity. Therefore, the objective of this study was to carry out scientific and technological monitoring of the pharmacological properties of rutin and its ...
Comparative analyses of metabolic fingerprint integrated with cytotoxic activit...
Guedes, Jhonyson Arruda Carvalho; Santiago, Yuri Gomes; dos Reis Luz, Licia; Silva, Maria Francilene Souza; Ramires, Christiane Mendes CassimiroMade available in DSpace on 2021-06-25T10:11:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Spondias species are a relevant source of natural-bioactive compounds in Brazilian folk medicine, and its biological potential has not been explored. Thus, this study aimed to determine the metabolomic fingerprint of Spondias mombin and Spondias tuberosa leaves based on the use of reversed-phase liquid ...
Investigação científica e tecnológica do efeito protetor da rutina na mucosite ...
Fideles, Lázaro de Sousa; Miranda, João Antônio Leal de; Pimentel, Paulo Vitor de Souza; Ribeiro, Maria Elenir Nobre PinhoA quimioterapia é um dos principais tratamentos oncológicos, no qual acarreta diversos efeitos colaterais, dentre os quais têm-se a mucosite. A rutina pertence à classe dos flavonoides e apresenta clinicamente funções relevantes, potencialmente benéficas na prevenção de doenças e atividade antioxidante. Portanto, objetivou-se com esse estudo, realizar um monitoramento científico e tecnológico acerca das proprie...
Perfil metabolômico e potencial citotóxico de Phyllanthus spp. (Phyllanthus ama...
Silva, Maria Francilene SouzaThe genus Phyllanthus belongs to Phyllanthaceae family, including the species Phyllanthus amarus and P. niruri, known as “quebra-pedra”. The use of natural products and its new chemical structures to develop new drugs are in focus the last years. New strategies as dereplication aim to fast the identification of the compounds from a crude extract or partial purified. The current study aims to evaluate the techno...
UPLC-HRMS and NMR applied in the evaluation of solid-phase extraction methods a...
Silva, Maria Francilene Souza; Silva, Lorena Mara A.; Quintela, Amanda Lemos; dos Santos, André Gonzaga [UNESP]; Silva, Francisca Aliny NunesMade available in DSpace on 2019-10-06T16:28:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-01; Empresa Brasileira de Pesquisa Agropecuária; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); The classical approach to drug discovery from natural products (NP's) requires strenuous and complex purification steps for the isolation and structural elucidation. Modern strategies as de...