469 documents found, page 1 of 47

O ensaio do micronúcleo em células da mucosa bucal: aplicabilidade em biomonito...

As exposições ambientais e ocupacionais a alguns agentes químicos ou físicos representam sérios riscos para a saúde humana. A biomonitorização humana (BMH) permite quantificar a exposição a substâncias químicas e seus efeitos precoces através da caracterização de biomarcadores de exposição e de biomarcadores de efeito. O ensaio do micronúcleo em células bucais (MNBMCyt) é um biomarcador precoce de genotoxicidad...

HBM4EU chromates study: the Portuguese integrated and harmonized study on expos...

In the scope of the European Union (EU) human biomonitoring initiative, a multicentric study on different occupational settings from several European countries was performed, to provide information on occupational exposure to hexavalent chromium [Cr(VI)], a known lung carcinogen. Biomonitoring approaches were used to obtain exposure data to support the implementation of new risk management measures and policy a...

Microalgae biomass–A source of sustainable dietary bioactive compounds towards ...

Microalgae are recognized as a promising plant-based protein source and are rich in bioactive compounds with potential health benefits. This review explores the role of microalgae bioactive compounds in global health, analysing findings from animal studies and human trials and their possible impact on health. It highlights the bioactive properties of microalgae, which enhance oral, cardiovascular, brain, gastro...

Biomonitorização humana e genotoxicidade ambiental: quatro décadas de investiga...

HBM4EU e-waste study – Occupational exposure assessment to chromium, cadmium, m...

Processing of electronic waste (e-waste) causes the release of toxic substances which may lead to occupational exposure. The study aimed to gather information on potential occupational exposure during e-waste recycling, with a focus on biomonitoring of chromium, cadmium, mercury and lead. In eight European countries, 195 workers involved in the recycling of lead batteries, white goods, brown goods and metals an...

HBM4EU E-waste study – An untargeted metabolomics approach to characterize meta...

E-waste contains hazardous chemicals that may be a direct health risk for workers involved in recycling. We conducted an untargeted metabolomics analysis of urine samples collected from male e-waste processing workers to explore metabolic changes associated with chemical exposures in e-waste recycling in Belgium, Finland, Latvia, Luxembourg, the Netherlands, Poland, and Portugal. Questionnaire data and urine sa...

Hazard characterization of the mycotoxins enniatins and beauvericin to identify...

Enniatins (ENNs) and beauvericin (BEA) are cyclic hexadepsipeptide fungal metabolites which have demonstrated antibiotic, antimycotic, and insecticidal activities. The substantial toxic potentials of these mycotoxins are associated with their ionophoric molecular properties and relatively high lipophilicities. ENNs occur extensively in grain and grain-derived products and are considered a food safety issue by t...

Regulatory practices on the genotoxicity testing of nanomaterials and outlook f...

Highlights: - Genotoxicity testing of chemicals requires multiple tests to cover key endpoints; - NMs have distinct properties that require adaptations of conventional testing; - Approaches for genotoxicity testing of the NMs reviewed show challenges; - The level of harmonization between different frameworks is debated; - New approach methodologies are underlined to support NMs'regulation.

Assessing the impact of TiO2 nanomaterials on intestinal cells: New evidence fo...

Understanding the potential impact of nanomaterials (NMs) on human health requires further investigation into the organ-specific nano-bio interplay at the cellular and molecular levels. We showed increased chromosomal damage in intestinal cells exposed to some of in vitro digested Titanium dioxide (TiO2) NMs. The present study aimed to explore possible mechanisms linked to the uptake, epithelial barrier integri...

A critical review to identify data gaps and improve risk assessment of bispheno...

Bisphenol A (BPA), a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins, has been associated with a variety of adverse effects in humans including metabolic, immunological, reproductive, and neurodevelopmental effects, raising concern about its health impact. In the EU, it has been classified as toxic to reproduction and as an endocrine disruptor and was thus included in ...