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Ketamine combined with psychotherapy for treatment-resistant depression

Cohen, Rebeca; Bastos, João; Cunha, Catarina; Marguilho, Miriam; Sancho, Ana; Silva, Maria João Matos; King, Franklin; Castro-Rodrigues, Pedro

Ketamine, an N -methyl- d -aspartate antagonist, shows promise for treatment-resistant depression (TRD), with psychedelic doses potentially enhancing efficacy. However, its transient antidepressant effects and the need for repeated infusions raise concerns about optimal duration and long-term safety. Two clinical trials have tested the combination of ketamine with psychotherapy for depression, with mixed result...

Date: 2026   |   Origin: Repositório Institucional da UNL
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