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INPP5K controls the dynamic structure and signaling of wild-type and mutated, l...

Moës, Bastien; Li, Hua; Molina-Ortiz, Patricia; Radermecker, Coraline; Rosu, Adeline; Vande Catsyne, Charles-Andrew; Sayyed, Sufyan Ali; Fontela, João

The downstream signaling of the interleukin-7 (IL-7) receptor (IL-7R) plays important physiological and pathological roles, including the differentiation of lymphoid cells and proliferation of acute lymphoblastic leukemia cells. Gain-of-function mutations in the IL-7Rα chain, the specific component of the receptor for IL-7, result in constitutive, IL-7-independent signaling and trigger acute lymphoblastic leuke...

Date: 2023   |   Origin: Repositório da Universidade de Lisboa
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