13 documents found, page 1 of 2
Update of the safety assessment of N,N‐bis(2‐hydroxyethyl)alkyl(C8‐C18)amines (...
EFSA Panel on Food Contact Materials (FCM); Lambré, Claude; Crebelli, Riccardo; Silva, Maria Joao; Grob, Konrad; Lampi, Evgenia; Milana, Maria RosariaThe European Commission asked EFSA to review whether the authorisation of N,N‐bis(2‐hydroxyethyl)alkyl(C8‐C18)amine (FCM No 19) and N,N‐bis(2‐hydroxyethyl)alkyl(C8‐C18)amine hydrochlorides (FCM No 20) is still in accordance with Regulation (EC) No 1935/2004, as provided for in Article 12(3). The FCM Panel concluded that some uses of the substance N,N‐bis(2‐hydroxyethyl)alkyl(C8‐C18)amine (FCM No 19) are not in ...
Physiologically based toxicokinetic models in aggregate exposure: A review
Lamon, L.; Paini, A.; Siccardi, M.; Doyle, J.; McNamara, C.; Galea, K.S.; Ghosh, M.; Louro, Henriqueta; Silva, Maria Joao; El Yamani, N.; Dusinska, M.This literature review explores the application of Physiologically Based Kinetic (PBK) models in aggregate exposure (AE) assessment across different chemical classes. It builds on the screening of 1119 publications and the identification of 40 relevant articles. The most frequently studied chemicals include volatile organic compounds and plant protection products, with metals, personal care products, persistent...
Hazard identification and characterization of leachable chemicals from plastic ...
Dirven, Hubert; Bogusz, Aleksandra; Hans Bouwmeester; Busch, Mathias; Duflos, Guillaume; Eriksen, Gunnar S.; Fardilha, Margarida; Flores-Gomez, DanielaA recent study has suggested that plastics may contain more than 16,000 chemicals, including additives, processing aids, starting substances, intermediates and Non-Intentionally Added Substances. Plastic chemicals are released throughout the plastic life cycle, from production, use, disposal and recycling. Most of these chemicals have not been studied for potential hazardous properties for humans and in the env...
Safety assessment of the substances ‘wax, rice bran, oxidised’ and ‘wax, rice b...
EFSA Panel on Food Contact Materials; Lambré, C.; Crebelli, R.; Silva, Maria Joao; Grob, K.; Lampi, E.; Milana, M.R.; Pronk, M.; Ščetar, M.The EFSA Panel on Food Contact Materials (FCM) assessed the safety of the substances ‘wax, rice bran, oxidised’ and ‘wax, rice bran, oxidised, calcium salt’, used as additives up to 0.3% in polyethylene terephthalate (PET), polyamide (PA), thermoplastic polyurethane (TPU), polylactic acid (PLA) and poly(vinyl chloride) (PVC) in contact with all food types for long‐term storage at room temperature and below, aft...
Evaluation of the cyto- and genotoxicity of two types of cellulose nanomaterial...
Vital, Nádia; Cardoso, Maria; Kranendonk, Michel; Silva, Maria Joao; Louro, HenriquetaEmerging cellulose nanomaterials (CNMs) may have commercial impacts in multiple sectors, being their application particularly explored in the food sector. Thus, their potential adverse effects in the gastrointestinal tract should be evaluated before marketing. This work aimed to assess the safety of two CNMs (CNF–TEMPO and CMF–ENZ) through the investigation of their cytotoxicity, genotoxicity (comet and micronu...
New approach methodologies to enhance human health risk assessment of immunotox...
Snapkow, Igor; Smith, Nicola M.; Arnesdotter, Emma; Beekmann, Karsten; Blanc, Etienne B.; Braeuning, Albert; Corsini, Emanuela; Sollner Dolenc, MarijaAs a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity, increased risk of autoimmune diseases and cancer development. At present, the regulatory assessment of the immuno...
Exposição Humana a Micotoxinas: biomonitorização humana e contribuição para a a...
Alvito, Paula; Silva, Maria JoaoAs populações estão expostas diariamente a uma mistura complexa de substâncias químicas maioritariamente através da alimentação. Por forma a avaliar a exposição humana a estes contaminantes, é importante efetuar a sua biomonitorização, isto é, detetar a sua presença diretamente em amostras biológicas como sangue, cabelo, urina ou leite materno, ou prever precocemente os seus efeitos no organismo, com vista a re...
Biological impact of metal nanomaterials in relation to their physicochemical c...
Louro, Henriqueta; Saruga, Andreia; Santos, Joana; Pinhão, Mariana; Silva, Maria JoaoSeveral metal and metal oxide nanomaterials (NMs), e.g., cerium dioxide NMs(CeO2), barium sulphate NMs(BaSO4) and titanium dioxide NMs(TiO2), display advantageous properties over the bulk materials and have a broad range of innovative applications in food, industry and consumer products. Whether these materials are hazardous and impact on human health or the environment remains an issue that needs to be address...
Aula 4: Estudos de Biomonitorização Humana
Louro, Henriqueta; Silva, Maria Joao1. Biomonitorização humana e Tipos de Biomarcadores 2. Exemplo de Aplicação: biomonitorização da exposição humana a fumo de tabaco ambiental em contexto ocupacional 3. A Iniciativa Europeia de Biomonitorização (HBM4EU) 4. Conclusões
Factors affecting the transfer of learning to the workplace
Veloso, Ana Luísa de Oliveira Marques; Silva, Maria Joao; Silva, Isabel Maria Soares da; Caetano, AntonioTraining aims to respond to the needs of development of individuals and organizations (Grohmann & Kauffeld, 2013). Based on Holton model, we carried out a study seeking to identify and understand the factors involved in the process of learning transfer to the workplace from two different training actions on the design and skills. The study took place at a Portuguese organization and involved 98 participants. Fo...